BACKGROUND Endothelial cells (EC) in tumor and normal tissue constitute critical radiotherapy targets. MicroRNAs have emerged as master switchers of the cellular transcriptome. Here, we seek to investigate the role of miRNAs in primary human dermal microvascular endothelial cells (HDMEC) after ionizing radiation. METHODS The microRNA status in HDMEC after 2 Gy radiation treatment was measured...

Vascular endothelial growth factor (VEGF) is a proangiogenic factor upregulated in many tumors. The alternative splicing of VEGF mRNA renders 3 major isoforms of 121, 165 and 189 amino-acids in humans (1 less amino-acid for each mouse VEGF isoform). We have designed isoform specific real time QRT-PCR assays to quantitate VEGF transcripts in mouse and human normal and malignant prostates. In the...

Susceptibility to transmissible spongiform encephalopathies (TSEs) is associated strongly with PrP polymorphisms in humans, sheep and rodents. In mice, scrapie incubation time is controlled by polymorphisms at PrP codons 108 (leucine or phenylalanine) and 189 (threonine or valine), but the precise role of each polymorphism in the control of disease is unknown. The L108F and T189V polymorphisms ...

We present the radial-velocity follow-up of two Kepler planetary transiting candidates (KOI-189 and KOI-686) carried out with the SOPHIE spectrograph at the Observatoire de Haute Provence. These data promptly discard these objects as viable planet candidates and show that the transiting objects are in the regime of very low-mass stars, where a strong discrepancy between observations and models ...

Treatment of tuberculosis (TB) and HIV co-infections is often complicated by drug-to-drug interactions between anti-mycobacterial and anti-retroviral agents. Rifabutin (RFB) is an alternative to rifampin (RIF) for TB regimens and is recommended for HIV patients concurrently receiving protease inhibitors because of reduced induction of CYP3A4. This study sought to determine the proportion of RFB...

[This corrects the article on p. 189 in vol. 9, PMID: 28659788.].

s and posters .............................................................................................................. 184 Supplementary files ................................................................................................................. 189 Abstract / Résumé.........................................................................................................211 Résu...