نتایج جستجو برای: آگلوتیناسیون مستقیم dat
تعداد نتایج: 41600 فیلتر نتایج به سال:
Glutamate or a related excitatory amino acid is thought to be the major excitatory neurotransmitter of hippocampal afferents, intrinsic neurons, and efferents. We have used an autoradiographic technique to investigate the status of excitatory amino acid receptors in the hippocampal formation of patients dying with dementia of the Alzheimer type (DAT). We examined L-[3H]glutamate binding to sect...
Cocaine addiction is a worldwide public health problem for which there are no established treatments. The dopamine transporter (DAT) is suspected as the primary target mediating cocaine's abuse-related effects based on numerous pharmacological studies. However, in a previous study, DAT knockout mice were reported to self-administer cocaine, generating much debate regarding the importance of the...
BACKGROUND To date the involvement of dopamine system in neurobiology of panic disorder (PD) has been not investigated by imaging studies in humans. In this study, we evaluated the binding potential of dopamine transporter (DAT) in striatum of patients with PD. METHODS Subjects comprised seven female patients with current PD, seven female PD patients in remission and seven female healthy cont...
OBJECTIVE To test the hypothesis that semantic impairment is present in both patients with dementia with Lewy bodies (DLB) and those with dementia of Alzheimer's type (DAT). METHODS A comprehensive battery of neuropsychological tasks designed to assess semantic memory, visuoperceptual function, verbal fluency, and recognition memory was given to groups of patients with DLB (n=10), DAT (n=10) ...
Cocaine produces its reinforcing effects primarily by inhibiting the dopamine transporter (DAT) at the level of presynaptic terminals and increasing extracellular levels of dopamine (DA). Surprisingly, in mice genetically lacking the DAT, cocaine was still able to elevate DA in the nucleus accumbens (NAc). This finding is critically important for explaining the persistence of cocaine reinforcem...
OBJECTIVE Gender differences are a well-known clinical characteristic of Parkinson's disease (PD). In-vivo imaging studies demonstrated that women have greater striatal dopamine transporter (DAT) activity than do men, both in the normal population and in PD patients. We hypothesize that women exhibit more rapid aging-related striatal DAT reduction than do men, as the potential neuroprotective e...
Drugs that target the dopamine transporter (DAT) have been proposed as pharmacotherapies to treat cocaine abuse. Accordingly, it is paramount to understand pharmacological interactions between cocaine and DAT inhibitors. The present study characterized acute interactions between cocaine and several DAT inhibitors (RTI-177, FECNT, RTI-112) that differed in selectivity for monoamine transporters ...
BACKGROUND Maternal care (MC) and dopamine modulate brain activity during emotion processing in inferior frontal gyrus (IFG), striatum and amygdala. Reuptake of dopamine from the synapse is performed by the dopamine transporter (DAT), whose abundance is predicted by variation in its gene (DAT 3'VNTR; 10 > 9-repeat alleles). Here, we investigated the interaction between perceived MC and DAT 3'VN...
متداول‌ترین روش‌های مورد استفاده برای تعیین آنتی‌بادی‌های ضد اسپرم آزمون اتصال ایمونویید و واکنش آگلوتیناسیون مختلط می‌باشند. تعیین ASA با روش فلوسیتومتری اولین‌بار به‌وسیلهHaas و Cunningham شرح داده شد. هر دو روش می‌توانند به‌طور مستقیم یا غیرمستقیم انجام شوند. در این مطالعه FCM غیرمستقیم با MAR مستقیم جهت تعیین آنتی‌بادی‌های ضداسپرم مقایسه گردیده است روش بررسی مایع منی مردان 80 زوج نابارور مر...
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