نتایج جستجو برای: آنزیم mva
تعداد نتایج: 13519 فیلتر نتایج به سال:
It has recently been suggested that bisphOsphOnateS may have directantitumor effects in vivo, in addition to their therapeutic antiresorptiveproperties. Bisphosphonates can inhibit proliferation and cause apoptosis inhuman myeloina cells in vitro. In macrophages, bisphosphonate-induced apoptosis was recently found to be a result of inhibition of the mevalonate(MVA) pathway. ...
The aim of this study was to evaluate the effect application biourin fertilizer and Mycorrhizal Vesicles Arbuscula (MVA) dosage on P dynamics, uptake yield shallots in vertisols. This designed with a factorial design pattern basis randomized block (RBD). treatment tested concentration (B), four levels: B10: Concentration 10 ml.l-1 water, B20: 20 B30: 30 water B40: 40 water. second MVA dose leve...
BACKGROUND Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified vaccinia Virus Ankara (MVA) vectored vaccines is a strategy recently shown to be capable of inducing strong cell mediated responses against several antigens from the malaria parasite. ChAd63-MVA expressing the Plasmodium falciparum pre-erythrocytic antigen ME-TRAP (multiple epitope string with t...
AIMS PTMC produces significant changes in mitral valve morphology as improvement in leaflets mobility. The determinants of such improvement have not been assessed before. METHODS AND RESULTS The study included 291 symptomatic patients with mitral stenosis undergoing PTMC. Post-PTMC subvalvular splitting area was a determinant of post-PTMC excursion in both the anterior (B 0.16, 95% CI 0.03 to...
The poxvirus strains NYVAC and MVA are two candidate vectors for the development of vaccines against a broad spectrum of diseases. Although these attenuated virus strains have proven to be safe in animals and humans, little is known about their comparative behavior in vitro. In contrast with MVA, NYVAC infection triggers greater cytopathic effect in a range of permissive and nonpermissive cell ...
The mevalonate (MVA) pathway is involved in cell proliferation. We investigated drugs acting at different enzymatic steps on rat aorta smooth muscle cell (SMC) proliferation. Competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (0.1-10 microM) dose-dependently decreased (up to 90%) SMC proliferation. This effect was prevented by 100 microM MVA, 10 microM all-trans farnesol ...
Various species of [2-14C] MVA stereospecifically labelled with tritium at C-2, C-4 and C-5 have been used to study details of carotenoid biosynthesis in a variety of preparations including chioroplasts, fruit and root slices, and fungi. Mechanisms have been proposed for the dimerization of geranylgeranyl pyrophosphate to form phytoene, for the cyclization of acyclic precursors to form aand a-c...
BACKGROUND High levels of continuous neck pain after a motor vehicle accident (MVA) are reported in cross-sectional studies. Knowledge of this association in general practice is limited. AIM To compare the differences in perceived pain and disability in patients with acute neck pain due to an MVA versus other self-reported causes. The secondary aim was to identify prognostic factors for conti...
BACKGROUND Patients with acute coronary artery thrombosis often develop primary malignant ventricular arrhythmias (MVA) early after coronary occlusion. In contrast, acute ischemia induced by nonthrombotic balloon occlusion during routine coronary angioplasty rarely elicits such arrhythmias. This study was designed to assess the role of intracoronary thrombosis in arrhythmogenesis during acute i...
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