نتایج جستجو برای: آنزیم kcs
تعداد نتایج: 12161 فیلتر نتایج به سال:
Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we show that hPSC-KCs self-organize into kidney organoids that functionally recapitulate tissue-specific epithelial physiology, including disease phenotypes after genome editing. I...
Persistent infections with a high-risk type human papillomavirus (hrHPV) can progress to cancer. High-risk HPVs infect keratinocytes (KCs) and successfully suppress host immunity for up to two years despite the fact that KCs are well equipped to detect and initiate immune responses to invading pathogens. Viral persistence is achieved by active interference with KCs innate and adaptive immune me...
The Drosophila mushroom body (MB) is an associative learning network that is important for the control of sleep. We have recently identified particular intrinsic MB Kenyon cell (KC) classes that regulate sleep through synaptic activation of particular MB output neurons (MBONs) whose axons convey sleep control signals out of the MB to downstream target regions. Specifically, we found that sleep-...
We describe a model – Proteus, for clinical protocols created with clinical knowledge represented as components. By applying principles of distributed computing the knowledge can be managed by experts at other locations while it is available to the clinicians as executable elements for decision support. Editability in the hands of users is essential for the success of any decision support syste...
Cell fate commitment during development is achieved through the expression of lineage-specific transcription factors. Recent studies have suggested that the expression of combinations of these lineage-specific transcription factors can convert adult somatic cells from one type to another. Here we report that the combination of p63, a master regulator of epidermal development and differentiation...
A clinicopathological correlation was performed on 24 patients suffering from keratoconjunctivitis sicca (KCS). Examination of conjunctival biopsies by light and transmission electron microscopy revealed stratification of the conjunctival epithelium with separation of the superficial cell layers, and this was directly proportional to the clinical severity of the disease. Counts of goblet cells ...
Keratoconjunctivitis Sicca (KCS), also known as “dry eye syndrome”, is a common ocular disease in dogs, caused by inflammation of the lacrimal gland, resulting decreased tear production. Efforts are being made to develop alternative therapies order prevent lifelong use drugs for patients with KCS. Mesenchymal stem cells (MSCs) be effective treatment many immune-mediated diseases human and anima...
Sexual dimorphism contributes to autoimmune diseases, such as systemic lupus erythematosus (SLE), where the female-to-male ratio is 9:1. Although hormonal and sex chromosome variation contribute women being more prone predominant driving mechanism(s) remain unknown. We hypothesize that male female keratinocytes display distinct differences in chromatin landscape nucleosome accessibility enforce...
N6-methyladenosine (m6A) is the most prevalent internal modification of mRNA in eukaryotes, and it involved various biological pathological processes. Psoriasis atopic dermatitis (AD) are considered as common chronic inflammatory skin diseases, both them feature epidermal acanthosis, hyperkeratosis, parakeratosis, infiltration immune cells well dermal changes. To reveal effect m6A keratinocytes...
In order to recover the energy loss due throttling in path of ammonia-lean solution Kalina Cycle System (KCS) 34, two redesigned cycles, which single-screw expanders that can perform two-phase expansion are used replace throttle valve, proposed this paper. The results show thermal efficiency and net work cycles higher than those original KCS 34. With concentration increase ammonia-water mixture...
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