Rat and human ribosomal RNA gene fragments in supercoiled plasmids were examined for S1 nuclease hypersensitivity. In the transcribed portion of genes the number and distribution of S1 sites were found to be species specific. No S1 sites were detected in the promoter regions. In the nontranscribed spacer (NTS), downstream of the 3' end of 28S RNA gene, S1 sites appear to be conserved in rat and...

To better characterize the conformational differences of G- and F-actin, we have compared the interaction between G- and F-actin with myosin subfragment 1 (S1) which had part of its F-actin binding site (residues 633-642) blocked by a complementary peptide or "antipeptide" (Chaussepied, P., and Morales, M. F. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 7471-7475). Light scattering, sedimentation, ...

We evaluated the effects of s1-receptor inhibition on m-opioid– induced mechanical antinociception and constipation. s1-Knockout mice exhibited marked mechanical antinociception in response to several m-opioid analgesics (fentanyl, oxycodone, morphine, buprenorphine, and tramadol) at systemic (subcutaneous) doses that were inactive in wild-type mice and even unmasked the antinociceptive effects...

The rate and equilibrium constants for the formation and dissociation of the bovine ventricular (BV) actomyosin-S1-ADP have been measured by stopped flow light scattering. A comparison of the rate constants obtained here with those for rabbit skeletal (RS) actomyosin-S1 indicates that there are large differences in several of the rate and equilibrium constants. 1) The rate constant of ADP disso...

The core oscillator model is described in section 2.2 of the paper but not all of the equations are stated explicitly. We state the full set of equations in the current section. The core oscillator model is a system of partial differential equations (PDEs) with two independent space variables, x and y, and the independent time variable t. It is defined on two regions, namely the nucleus and cyt...

Keywords--Pala is-Smale condition, Critical point theory, Hamiltonian systems, Perturbation from symmetry, Multiple periodic solutions. 1. I N T R O D U C T I O N In this paper, in the spirit of [1], we want to investigate the effect of perturbing the S l symmet ry of a general class of Hamiltonian systems. Studied around 1980 by Bahri and Berestycki in [2], the problem of finding multiple peri...

The main result of this note is that every closed Hamiltonian S manifold is uniruled, i.e. it has a nonzero Gromov–Witten invariant one of whose constraints is a point. The proof uses the Seidel representation of π1 of the Hamiltonian group in the small quantum homology of M as well as the blow up technique recently introduced by Hu, Li and Ruan. It applies more generally to manifolds that have...

Assuming axial symmetry, we introduce a surface of revolution approach to model the membrane at equilibrium. We consider a generating curve γ parameterized by arc length s lying in the x− z plane. The curve γ is expressed as γ(0, s1) → R γ(s) = (R(s), 0, z(s)) (S1.1) where s1 is the total arc-length. This generating curve leads to a global parametrization of the membrane expressed as X : (0, s1...