Im Gegensatz zu Iod(I)-basierten Halogenbrückendonoren wurden von Iod(III) abgeleitete Derivate nur in einer Handvoll Beispielen als einzähnige Lewis-saure Organokatalysatoren verwendet. Hier berichten wir der ersten Anwendung zweizähniger Bis(iodolium)salze Michael- und Nitro-Michael-Additionsreaktion sowie Diels-Alder-Reaktion, welche bisher noch nicht nicht-kovalenten aktiviert worden war. I...

A two-step transition metal-free methodology for the C(sp3)?C(sp3) functionalisation of saturated N-heterocyclic systems is disclosed. First, aminal derivatives are generated through anodic oxidation readily accessible carboxylic acids. Then, in presence BF3 ? OEt2, iminium ions unmasked and rapidly alkylated by organozinc reagents under flow conditions. Secondary, tertiary quaternary carbon ce...

We report a new method developed for the determination of stable carbon isotopic composition of homologous alpha,omega-dicarboxylic acids and phthalic acid isolated from environmental samples such as atmospheric aerosols and snow. Dicarboxylic acids are derivatized with BF3/1-butanol to dibutyl esters, which are analyzed for the stable carbon isotopic composition using a capillary GC interfaced...

Among privileged structures, indoles occupy a central place in medicinal chemistry and alkaloid research. Here we report a flexible and efficient conversion of pyrrole-3-carboxaldehydes to substituted 7-amino-5-cyanoindoles. Phosphine addition to fumaronitrile proceeds with prototropic rearrangement of the initially formed zwitterion to the thermodynamically favored phosphonium ylide, which is ...