Ann Surg Oncol. 2007 Dec;14(12):3620-8. Inhibition of proliferation by omega-3 fatty acids in chemoresistant pancreatic cancer cells. Hering J, Garrean S, Dekoj TR, Razzak A, Saied A, Trevino J, Babcock TA, Espat NJ. Department of Surgery, University of Illinois at Chicago, Chicago, Illinois, USA. BACKGROUND: Pancreatic cancer-gemcitabine (GEM) chemoresistance has been demonstrated to be associ...

1 Abstract The GEM compiler system is the technology Digital is using to build state-of-the-art compiler products for a variety of languages and hardware /software platforms. Portable, modular software components with carefully specified interfaces simplify the engineering of diverse compilers. A single optimizer, independent of the language and the target platform, transforms the intermediate ...

Measurements and numerical simulations on the charge transfer in Gas Electron Multiplier (GEM) foils are presented and their implications for the usage of GEM foils in Time Projection Chambers are discussed. A small test chamber has been constructed and operated with up to three GEM foils. The charge transfer parameters derived from the electrical currents monitored during the irradiation with ...

PROJECT DESCRIPTION The overall objective of this project is the development of maize varieties with host plant resistance against the Western corn rootworm (WCR), the European corn borer (ECB), and Fusarium by searching for novel resistance genes and alleles available in GEM base populations. The breeding activities comprise intensive evaluation of GEM germplasm for multiple insect and Fusariu...

PURPOSE The aim of the study was to evaluate the activity of epidoxorubicin (EPI) and gemcitabine (GEM) and to define the most effective schedule in human bladder cancer cells. EXPERIMENTAL DESIGN The study was performed on HT1376 and MCR cell lines. Cells were exposed for 1 and 24 h to drugs used in different schemes. Cytotoxic activity was evaluated by the sulforhodamine B assay, potential ...

Starting from easily accessible gem-difluoropropargylic derivatives, a DBU-mediated isomerisation affords enones in fair yields with a gem-difluoroalkyl chain. These derivatives were used to prepare pyrazolines and pyrrolines with the desired gem-difluoroalkyl side chain by cyclocondensations in good yields and with excellent stereoselectivity. A one-pot process was also successfully developed ...

AIMS Whether gemcitabine based chemoradiotherapy (GEM-based CRT) is superior to 5-fluorouracil based chemoradiotherapy (5-FU-based CRT) for locally advanced pancreatic cancer (LAPC) remains uncertain. The aim of the present study was to evaluate the effect of GEM-based CRT compared with 5-FU-based CRT. METHODS Electronic database including Medline, Embase, Cochrane controlled trials register,...

A series of observations have indicated that tau, one of the major microtubule-associated proteins, is involved in neuronal cell morphogenesis and axonal maintenance. Tau is also the major component of paired helical filaments found in brains affected by Alzheimer's disease. To explore an as yet unidentified role of tau in vivo, approximately 11,000 mRNAs were profiled from tau-deficient mouse ...