The Food and Drug Administration (FDA) creates the climate for the development of new drugs and clinical research. A 30 year struggle to bring drugs to the market more rapidly culminated in the 1992 Prescription Drug User Fee Act (PDUFA). While drug review times have shortened, concerns about drug safety possibly associated with more rapid reviews have led FDA and Congress to tighten safety req...

1 Departments of Functional Genomics and Clinical Genetics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit (VU) and VU Medical Center, 1081 HV Amsterdam, Netherlands 2 Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany 3 Department of Genetics and Medicine, University of Pennsylvania,...

As scoliotic curve is a rotational deformity, derotation maneuvre was used as the corrective factor, but recent studies demonstrated spinal imbalance and decompensation problems in patients treated with this method. This study evaluates 217 late onset idiopathic scoliosis patients surgically treated with third generation instrumentation (Texas Scotish Rite Hospital System - TSRH) from September...

Restructuring of the US electric power system that began in the late 1990’s appears to have run aground over the question of the assurance of both regulatory resource adequacy and generator long-term revenue sufficiency. The energy and capacity markets that have been designed for a number of the centralized markets in the US and elsewhere have not functioned as designed. Energy only markets suc...

Cystolithiasis merupakan keadan ditemukan urolith/kalkuli pada vesika urinaria (VU) yang disebabkan oleh multifaktorial yaitu dipengaruhi pH urin, pakan, dan infeksi bakteri. Seekor kucing ras campuran berwarna orange, jenis kelamin jantan, berumur empat tahun, dengan bobot badan 5,2 kg diperiksa di Klinik Hewan Prema, Dalung, Bali, keluhan tidak kencing selama 5 hari, lemas, penurunan nafsu ma...

Ð An explanatory mechanism is discussed that leads to a so-called sufficiency theory of certain psychological phenomena, such as standard recognition as opposed to deÂjaÁ vu, imagined novel experience, jamais vu, disturbed recognition, incorrect recognition, and hallucinationÐexperiences that have not been explained before in a satisfactory scientific manner. Sufficiency theory, in general, mea...

Political debate over medical malpractice reform seldom takes meaningful account of its policy context, including the emerging science of patient safety. Instead, stakeholders on both sides use the rhetoric of patient safety to support entrenched positions on hardened proposals such as capping damages and limiting access to information about errors. Despite its déjà vu quality, the current malp...