PURPOSE Recent findings indicating that many genes related to cancer development are silenced by an aberrant DNA methylation suggest that inhibitors of this process may be effective cancer therapeutics. In this study we investigated the efficacy of low-dose 5-aza-2'-deoxycitydine (DAC), a methylation inhibitor, with interleukin (IL) 12, one of the most potent cytokines with antitumor activity. ...

BACKGROUND Ductal adenocarcinoma (DAC) of the prostate is an uncommon histologic subtype whose prognostic factors and immunoprofile have not been fully defined. METHODS To define its prognostic factors and immunoprofile, the clinicopathological features, including biochemical recurrence (BCR), of 61 cases of DAC were analyzed. Immunohistochemistry was performed on tissue microarray constructs...

Cerebral dopamine neurotrophic factor (CDNF) and mesencephalic astrocyte-derived (MANF) are involved in neuroprotection mitigating endoplasmic reticulum (ER) stress the brain peripheral organs. In earlier work, an increase histone acetylation, following treatment with epigenetic modulator, valproic acid, was associated induction of CDNF MANF cultured cells rat brain. These findings prompted inv...

O desenvolvimento e o uso de materiais bioativos que permitem a manutenção dos tecidos dentários são os pilares da abordagem minimamente invasiva. No entanto, durabilidade união adesiva dentina ainda não é completamente satisfatória, principalmente em afetada por cárie (DAC). Assim, objetivo foi avaliar influência incorporação direta do vidro bioativo (BAG) 10% um sistema adesivo autocondiciona...

A novel scheme of photonic aided vector millimeter-wave (mm-wave) signal generation without a digital-to-analog converter (DAC) is proposed. Based on our scheme, 20 Gb/s 4-ary quadrature amplitude modulation (4-QAM) mm-wave generated using DAC. The experiment results demonstrate that the bit error rate (BER) 4-QAM can reach below hard-decision forward-error-correction threshold after delivery o...

The objective of the current study is to evaluate and determine effect monomer concentration ClAETA on grafting copolymerization oxidized cellulose which isolated from peel durian. Four concentrations were used in this study, e.g., 40, 50, 60, 70%. Several analyses performed material characteristic, degree grafting, FT-IR, surface morphology, contact angle, swelling, antibacterial activity. res...

Background: Coronary computed tomography angiography (CCTA) allows for noninvasive coronary artery disease (CAD) phenotyping. Factors related to CAD progression are epidemiologically valuable. Objective: To identify factors associated with CAD progression in patients undergoing sequential CCTA testing. Methods: We retrospectively analyzed 384 consecutive patients who had at least two CCTA s...