The ATP-sensitive K+ (KATP) channel controls blood glucose levels by coupling metabolism to insulin secretion in pancreatic β-cells. E23K, a common polymorphism the pore-forming KATP subunit (KCNJ11) gene, has been linked increased risk of type 2 diabetes. Understanding risk-allele-specific pathogenesis potential improve personalized diabetes treatment, but underlying mechanism remained elusive...

Powders based on β-tricalcium phosphate (β-TCP) containing sulphate groups at up to 12.0 mol.% were synthesised by chemical precipitation from aqueous solutions. The obtained materials characterised X-ray phase analysis, Fourier transform infrared spectroscopy, measurement of specific surface area, scanning electron microscopy, energy dispersive synchronous thermal mass spectra investigations a...

Background: Preeclampsia is a common pregnancy-specific disorder associated with significant maternal and fetal morbidity and mortality worldwide. It has been proposed that the imbalance between two CD4+ T cell subtypes, regulatory T cells (Treg) and T-helper 17 cells (Th17), is involved in the pathophysiology of preeclampsia. Objectives: To determine the serum levels of IL-17, IL-21, IL-23 and...

We recently reported the scalable in vitro production of functional stem cell-derived β-cells (SC-β cells). Here we extend this approach to generate the first SC-β cells from type 1 diabetic patients (T1D). β-cells are destroyed during T1D disease progression, making it difficult to extensively study them in the past. These T1D SC-β cells express β-cell markers, respond to glucose both in vitro...

Curcumin (CUR) is the active curcuminoid with many physiological, biochemical, and pharmacological properties. Solubility and stability of CUR is the limiting factors for realizing its therapeutic potential. Bovine β-casein is an abundant milk protein that is highly amphiphilic and self-assembles into stable micellar nanoparticles in aqueous solution. β-Casein nanoparticle can solubilize CUR mo...

multiple sclerosis (ms) is an autoimmune disease of the central nervous system (cns) which causes demyelination of the nerve fibers. the etiology of this disease is not well understood but it is believed that t helpers play a central role in ms. numerous findings support the view that th17 cells play an essential role in pathogenesis of ms and il-17 secreting t (th17) cells have a role in infla...

Introduction Blood sugar homeostasis relies largely on the action of pancreatic islet hormones, particularly insulin and glucagon. In a prototypical fashion, glucagon is released upon hypoglycemia to elevate glucose by acting liver while elevated induces secretion which leads uptake peripheral tissues. This simplified view does not consider paracrine roles two hormones modulating response α- β-...

We’ve previously shown that high levels of selenoprotein P (SeP), a major in plasma, can be risk factor type 2 diabetes. It was also thought inhibition insulin secretion caused by over-supplementation selenium SeP to pancreatic β cells contributed the progress On other hand, methylmercury, which is an environmental pollutant, known cancel action via covalent modification. Therefore, we interact...

Purpose: To investigate how WW domain-containing oxidoreductase (WWOX) gene affects epithelial-mesenchymal transition (EMT) of ovarian cancer (OC) cells, and the implication Elf5/Snail-1 pathway in process.
 Methods: This study employed female BALB/c nude mice aged 6 weeks. The expression levels E-cadherin, β-Catenin, N-cadherin, Vimentin, Snail1 Elf5 were assayed using qRT-PCR. protein WW...