Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications.The development of multicomponent reactions designed to produce elaborate biologically active compounds has become an important area of research in organic, combinatorial, and medicinal chemistry. in this Manuscript, a facile and efficient multicomponent synthesis of functional...

In the present study, the synthesis of diethylene triamine supported on cellulose biopolymer as a biodegradable solid basic heterogeneous catalyst was suggested. Then, the applicability of the synthesized catalyst cellulose bonded N-propyl diethylene triamine (CBPDETA) was tested for the synthesis of oxindole derivatives, an important class of potentially bioactive compounds. A various series o...

Diacetyl, a butter-flavoring component, has recently attracted scientific and media attention because it has been implicated as an agent that induces popcorn lung disease in exposed plant workers. This disease, officially referred to as bronchiolitis obliterans, entails exposure-induced compromise to the lung's epithelial barrier function. In this review, we present a novel molecular mechanism ...

Easily synthesized1-methyl-3-(2-oxyethyl)-1H-imidazol-3-ium-borate sulfonic acid {[MOEI]-BSA} as a novel catalyst efficiently promoted the synthesis of quinoxaline derivatives via condensation of various diamines with 1,2-dicarbonyl compounds at room temperature conditions in ethanol. This research provides a new method for the synthesis of quinoxalines in good to excellent yields with little c...

The inside cover picture illustrates the introduction of a catalyst-free three-component coupling reaction for synthesis 1,4-dicarbonyl compounds. This innovative process employs light-activated electron donor-acceptor complexes to initiate single-electron reduction via carboxylic acid derivatives, triphenylphosphine, and sodium iodide. Subsequently, decarboxylation fragmentation gives rise nuc...

This paper describes the applicability of 1,3-dichloro-5,5-dimethylhydantoin, as a cheap, stable and commercially available catalyst, in the promotion of the synthesis of 1,8-dioxo-octahydro-xanthenes (DOXOs) via the one-pot condensation of aldehydes and cyclic 1,3-dicarbonyl compounds. This novel synthetic method has the advantages of high yields, short reaction times, low cost and av...

In this research, we have developed cheap recyclable and task-specific acidic ionic liquids (AILs) 1-hydrogen-3-methylimidazolium hydrogen sulfate [Hmim]HSO4, 1-hydrogen-3-methylimidazolium chloride [Hmim]Cl, 2-pyrrolidonium hydrogensulfate [Hnhp]HSO4 and applied them in acid catalyzed synthesis of quinoxaline derivatives from 1,2-phenylendiamines and 1,2-dicarbonyl compounds. The products coul...