We report here the one-pot synthesis of 1,2,3-triazoles of arylboronic acids in water. An efficient method has been developed for the synthesis of 1,2,3-triazoles via a one-pot reaction of an arylboronic acid with sodium azide in the presence of Cu(2)-β-CD (CD = Cyclodextrin) as a nanocatalyst in water followed by a click cyclization reaction with an alkyne at room temperature in air without an...

Fluconazole was studied with two different hydrophilic cyclodextrins (hydroxypropyl-β-cyclodextrin (HPBCD) and sulfobutyl ether-β-cyclodextrin (SBECD)) for the formation of inclusion complexes. HPBCD and SBECD showed low cell cytotoxicity in human keratocytes as assessed by the label-free xCELLigence system for real-time monitoring. The fluconazole-HPBCD complex was incorporated into an ion-sen...

The poor water solubility of paclitaxel causes significant problems in producing cancer therapeutic formulations. Here, we aimed to solubilize paclitaxel using biocompatible cyclic carbohydrates. Generally recognized as safe, labeled β-cyclodextrin (β-CD), a cyclic α-1,4-glucan consisting of seven glucoses, was prepared, and bio-sourced cyclosophoraoses (CyS), which are unbranched cyclic β-1,2-...

Disulfiram (DS) has an excellent anti-viral activity; however, its low water-solubility and first-pass metabolism are limiting clinical applications. Cyclodextrins (CDs) have been used as solubility enhancers carriers of DS proposed for inhalation to treat SARS-CoV-19. Two types CDs (hydroxypropyl β-cyclodextrin sulfobutyl ether β-cyclodextrin) were form inclusion complexes wi...

The influence of oligosaccharides (α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin), a polysaccharide, sodium hyaluronate (NaHy), on the diffusion aqueous solutions cobalt chromium chlorides has been investigated. Cobalt are constituents metal alloys for biomedical use, including dental prostheses. Thus, release these ions in human body can lead to harmful biological effects. interaction with...

In this research, we report on the synthesis of mesoporous silicas with various quantities of immobilized oligosaccharide groups and different pore ordering degree. The hydrothermal co-condensation of tetraethyl orthosilicate and β-cyclodextrin-containing organosilane in the presence of cetyltrimethylammonium bromide template was employed. The purpose of this investigation was to show the oppor...

Ferric Species Standard ferric sulfate solutions were prepared by dissolving spectrographically pure iron rod (Johnson Matthey) in sulfuric acid and oxidizing with hydrogen peroxide. The decadic molar extinction coefficient of ferric ion in 0.8 N sulfuric acid at 24.9?C was found to be 2199 ? 4 liters mole-' cm-l at 304 m,/. The effect of a decrease of acidity and of added ferrous and cupric su...

Ramipril is used mainly for the treatment of hypertension and to reduce incidence of fatality following heart attacks in patients who develop indications of congestive heart failure. In the paediatric population, it is used most commonly for the treatment of heart failure, hypertension in type 1 diabetes and diabetic nephropathy. Due to the lack of a suitable liquid formulation, the current stu...