The thermal degradation and flammability characteristics of some common fibre-forming polymers, such as polypropylene (PP) polyacrylonitrile (PAN), are described in this review paper. flame retardance these polymers is principally affected by reactive routes that were primarily developed our laboratories. modifying groups incorporated into polymeric chains include phosphorus- or phosphorus/nitr...

The present study, for the first time, presents a feasible protocol for the preparation of β-cyclodextrin/ imidazolium based dicationic ionic liquid, [βCD/Im](OTs)2, and its application as an efficient and eco-friendly microvessel and host ionic liquid system for the regioselective ring opening of the epoxides in water. No evidence for the formation of diol by-products or side reacti...

Switchable β-cyclodextrin (β-CD)-induced hydrolysis of m-tert-butylphenyl acetate is demonstrated in the presence of supramolecular β-CD/adamantane oligonucleotide scaffolds. In one system, a duplex between a β-CD-functionalized nucleic acid and an adamantane-nucleic acid leads to a switchable catalytic system. In a second system, a β-CD/adamantane duplex is cooperatively generated by K(+)-stab...

Development and validation of a simple fast method high-performance liquid chromatography with diode array detection (HPLC-DAD) for the simultaneously analysis rutin, avobenzone, octyl p-methoxycinnamate is presented. These substances were separated using Kromasil C18 (250×4.6 mm, 5 μm) column, methanol: water (88:12 v/v) as mobile phase, flow rate 0.8 mL min−1. The experiment was performed at ...

Insulin glargine is a synthetic long-acting insulin product used for patients with diabetes mellitus. In this study, to obtain the further desirable blood-glucose lowering profile of insulin glargine, we investigated the effects of β-cyclodextrin sulfate (Sul-β-CyD) and sulfobutylether β-cyclodextrin (SBE7-β-CyD) on physicochemical properties of insulin glargine and pharmacokinetics/pharmacodyn...

The aim of this work is to improve physical properties and biological activities of the two flavanones hesperetin and naringenin by complexation with β-cyclodextrin (β-CD) and its methylated derivatives (2,6-di-O-methyl-β-cyclodextrin, DM-β-CD and randomly methylated-β-CD, RAMEB). The free energies of inclusion complexes between hesperetin with cyclodextrins (β-CD and DM-β-CD) were theoreticall...

Many biomolecules undergo conformational changes associated with allostery or ligand binding. Observing these changes in computer simulations is difficult if their timescales are long. These calculations can be accelerated by observing the transition on an auxiliary free energy surface with a simpler Hamiltonian and connecting this free energy surface to the target free energy surface with free...

The highly anionic synthetic pentasaccharide fondaparinux (FDPX) – representing the antithrombin binding sequence of heparin is in clinical use as a potent anticoagulant. Contrary to unfractionated heparin, FDPX lacks antidote completely reversing its anticoagulant activity, therefore it great importance identify new structures exhibiting strong intermolecular interactions towards FDPX. polycat...

Aqueous solubility is a critical factor for optimum drug delivery. In the present study, we investigated the potential of drugcyclodextrin complexation as an approach for improving the solubility and bioavailability of famotidine, an H2-receptor antagonist and acid reducing drug which has poor solubility and bioavailability. Solubility improvement of drug by βcyclodextrin was done by simple com...

Addition of β-Cyclodextrin to aqueous solutions of rhodamine B base results in the deaggregation of the dye to its monomer form. This is due to the association of monomeric rhodamine B base to the cyclodextrin. The absorption and emission spectra of the aqueous dye solution have been described. This has also been proved by UV-Vis, FTIR and Scanning Eelectron Microscope (SEM). Ground state (Kg) ...