Transgenic PDAPP mice, which express a disease-linked isoform of the human amyloid precursor protein, exhibit CNS pathology that is similar to Alzheimer's disease. In an age-dependent fashion, the mice develop plaques containing beta-amyloid peptide (Abeta) and exhibit neuronal dystrophy and synaptic loss. It has been shown in previous studies that pathology can be prevented and even reversed b...

Abbreviations: Aβ: Amyloid-β peptide; AD: Alzheimer Disease; ALS: Amyloid Lateral Sclerosis; APP: Amyloid Precursor Protein; (BBB): Blood-Brain Barrier; DA: Dopaminergic neurons; FGF: Fibroblasts Growth Factor; HD: Huntington Disease; L-DOPA: Laevo3,4 dihydroxyphenylalanine; MAPK: Mitogen Activated Protein Kinase; MS-818: 2-piperadino-6-methyl-5-oxo-5, 6-dihydro (7H) pyrrolo [2,3d] pyrimidine m...

Amyloid cascades that lead to peptide β-sheet fibrils and plaques are central to many important diseases. Recently, intermediate assemblies of these cascades were identified as the toxic agents that interact with cellular machinery. The location and cause of the transformation from a natively unstructured assembly to the β-sheet oligomers found in all fibrils is important in understanding disea...

The BRICHOS domain is associated with proliferative, degenerative and amyloid diseases, and it has been shown to inhibit fibril formation and toxicity of the Alzheimer's disease-associated amyloid β-peptide. ProSP-C (prosurfactant protein C) BRICHOS binds to stretches of hydrophobic amino acid residues, which are unfolded or in β-strand conformation, suggesting that it may have broad anti-amylo...

objective(s): neuroprotective effect of creatine (cr) against β-amyloid (aβ) is reported in an in vitro study. this study investigated the effect of cr supplementation on β-amyloid toxicity in vivo. materials and methods: thirty two, male wistar rats were divided into 4 groups. during ten weeks of study, control group went through no surgical or dietary intervention. at the 4th week of study sh...

Alzheimer's disease (AD) is a form of dementia and the most common progressive neurodegenerative disease (ND). The targeting of amyloid-beta (Aβ) aggregation is one of the most widely used strategies to manage AD, and efforts are being made globally to develop peptide-based compounds for the early diagnosis and treatment of AD. Here, we briefly discuss the use of peptide-based compounds for the...

Amyloid fibrils are formed by a model surfactant-like peptide (Ala)10-(His)6 containing a hexa-histidine tag. This peptide undergoes a remarkable two-step self-assembly process with two distinct critical aggregation concentrations (cac's), probed by fluorescence techniques. A micromolar range cac is ascribed to the formation of prefibrillar structures, whereas a millimolar range cac is associat...

The field of de novo protein design has met with considerable success over the past few decades. Heme, a cofactor, often been introduced to impart diverse array functions protein, ranging from electron transport respiration. In nature, heme is found occur predominantly in α-helical structures β-sheets, which resulted significant designs proteins utilizing coiled-coil helices. By contrast, there...