Protein phosphorylation keeps circadian clocks wound, triggering rhythmic transcriptional events throughout the day. This week, Lin et al. identify phosphorylation sites on the Drosophila circadian protein PERIOD (PER). Mutations in casein kinase 2 (CK2) result in abnormal circadian phenotypes and altered PER nuclear localization, and CK2 specifically phosphorylates PER in vitro. The authors fo...

34). Clayson (8) has pointed out that “. . . promoting agents must act by bringing about an increase in the number of precancerous or cancerous cells compared with the number of normal cells. . . .“While this selection for initiated cells may be accomplished in several different ways, a molecular basis for the selection is suggested based on the experiments described here. The process of pr...

it is not known whether such symptoms are generally experienced more often by patients in non-Western societies than among patients in the Western world. We are not aware of any multicultural study that has set out specifically to compare the prevalence of somatic symptoms in different ethnic groups using a comprehensive inventory of such symptoms. Many well established psychological scales suc...

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Career preferences among medical students are less influenced by the instruction provided than medical educators like to recognize. To a surprising extent career choice antedates the relevant training exposure, existing already in early medical school years (Schumacher, 1964). Career choice has been linked with personality type. “¿ Individualswho choose different types of medical careers have...

In [4] Kostant showed that the set of Iwasawa double cosets which intersect a given Cartan double coset in a semisimple Lie group corresponds to a certain convex subset in the Lie algebra of a maximal torus of the group. As a consequence, he established that representatives for the double cosets relative to a maximal compact subgroup of a semisimple Lie group may be chosen in the unipotent radi...

There are two main results we wish to state which are proved in a series of papers starting with [1]. The first is that whenever a particle which is undergoing motion governed by a strong Markov process with stationary transition probabilities and without holding points traces out a fixed trajectory segment, it must trace it out in a fixed length of time depending only on the transition probabi...

SINCE the introduction of curare to modify the contractions in E.C.T. , the use of relaxants has become standard psychiatric practice. These substances reduce the risk of fractures and enable treatment to be given to patients who would other wise be denied it owing to risks arising from concomitant physical disease. During recent years great efforts have been made to simplify the technique of m...

Background: Electromagnetic fields (EMF) with different intensities are widely used at home, offices and public places.Today, there is a growing global concern about the effects of human exposure to EMFs. Epilepsy is one of the most common chronic neurological diseases, affecting 50 million people of all ages worldwide. We aimed to investigate the effect of exposure to Wi-Fi radiation on epilep...

For both theoretical and practical considerations, it would be useful to understand the relationship between growth behavior of tissue culture cell lines and growth control of normal animal tissues in vivo. A review of pre vious attempts to determine this relationship suggested to us that 1 source of the discrepancies was the assay for tumonigenicity. After prolonged growth in the laboratory, a...