Article history: Received: 12 Mar 2011 Accepted: 15 Mar 2011 Available online: 26 May 2013 ZJRMS 2014 Aug; 16 (8): 1-5 In some studies, it is suggested that a number of dietary factors including essential fatty acid, iron and zinc deficiency, may be linked to attention-deficit/hyperactivity-disorder (ADHD). However, the exact mechanism of this relationship is yet unclear. The purpose of this st...

OBJECTIVE The aim of this study was to review the published evidence for a role of zinc nutrition in attention-deficit/hyperactivity disorder (ADHD). METHOD A computer literature search was supplemented by the authors' knowledge. RESULTS Numerous controlled studies report cross-sectional evidence of lower zinc tissue levels (serum, red cells, hair, urine, nails) in children who have ADHD, c...

Background: Attention deficit hyperactivity disorder is a common multifactorial and complex neuro developmental disorder often persisting through adolescence and adulthood. Indications of nutritional treatments with omega-3 fatty acids, and minerals like zinc, magnesium, iron, etc. are gaining importance. We therefore sought to estimate ,and compare the mineral content of zinc, magnesium, and i...

Zinc ions highly concentrate in hippocampus and play a key role in modulating spatial learning and memory. At a time when dietary fortification and supplementation of zinc have increased the zinc consuming level especially in the youth, the toxicity of zinc overdose on brain function was underestimated. In the present study, weaning ICR mice were given water supplemented with 15 ppm Zn (low dos...

Zinc is an important co-factor for metabolism relevant to neurotransmitters, fatty acids, prostaglandins, and melatonin, and indirectly affects dopamine metabolism, believed intimately involved in attention-deficit/hyperactivity disorder (ADHD). To explore the relationship of zinc nutrition to essential fatty acid supplement and stimulant effects in treatment of ADHD, we re-analyzed data from a...

There is concern regarding the absorption of zinc, both from dietary intake and nutritional supplements, because of zinc’s essential role in human nutrition and metabolism, and because of evidence that some population groups have a marginal to deficient intake of zinc. While oral zinc supplementation is efficacious in most zinc deficiency conditions, not all zinc preparations have equal bioavai...

Zinc is an endogenous modulator of neuronal activity and may play an important role in the pathogenesis of depression. Recent studies have shown that zinc exhibits antidepressant-like activity in some models of depression in rodents. Our previous studies have shown that the footshock-induced fighting behavior was reduced in the rats subjected to chronic unpredictable stress (CUS). This test is ...

OBJECTIVE It has been suggested that both low iron and zinc levels might be associated with Attention Deficit Hyperactivity Disorder (ADHD) symptoms. However, the association of zinc and iron levels with ADHD symptoms has not been investigated at the same time in a single sample. METHOD 118 subjects with ADHD (age = 7-14 years, mean = 9.8, median = 10) were included in the study. The relation...

OBJECTIVE The aim of this study was to explore the relationship of zinc nutrition to the severity of attention-deficit/hyperactivity disorder (ADHD) symptoms in a middle-class American sample with well-diagnosed ADHD. Previous reports of zinc in ADHD, including two positive clinical trials of supplementation, have come mainly from countries and cultures with different diets and/or socioeconomic...