In developing a drug delivery strategy, issues of absorption, distribution, metabolism, and elimination must be considered. The eye presents unique opportunities and challenges when it comes to the delivery of pharmaceuticals. While absorption by this route is bungling, there are few side effects with conventional ocular dosage forms. Hence, ocular inserts were prepared with prolonged release o...

Objective(s): The quantitative calculation of release data is more facil when mathematics come to help. mathematically modeling could aid optimizing and amending the delivery systems design. Aim of this study is to find out the isoniazid release kinetic. Methods: In this work degradable temperature sensitive dextran-hydroxy ethyl me...

this study examines the controlled release behavior of both water-soluble (acetaminophen, caffeine, theophylline and salicylic acid) and water insoluble (indomethacin) drugs derived from caesalpinia pulcherrima seed gum isolated from caesalpinia pulcherrima kernel powder. it further investigates the effect of incorporating diluents such as microcrystalline cellulose and lactose on caffeine rele...

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

it is possible to alter the permeability of ethyl cellulose membrane with certain materials such as surfactants. in this study the effect of surfactant concentration and different hlb values on the release rate of atenolol from ethyl cellulose-coated tablets was evaluated. the results showed that when the concentration of surfactant increased, the rate of drug release also increased. the kineti...

the aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...

controlled release swellable tablets of phenobarbital were prepared by a simple direct compression process using hydroxypropyl methylcellulose (hpmc) as the matrix former. the effects of the viscosity grades of hpmc and hpmc/lactose ratio and ethylcellulose (ec)/sodium carboxymethylcellulose (nacmc) and their concentrations on the release behavior of phenobarbital from hpmc matrices were invest...

It is possible to alter the permeability of ethyl cellulose membrane with certain materials such as surfactants. In this study the effect of surfactant concentration and different HLB values on the release rate of atenolol from ethyl cellulose-coated tablets was evaluated. The results showed that when the concentration of surfactant increased, the rate of drug release also increased. The kineti...

      The objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (DDS) for Metoprolol tartarate (MT) as tablet and capsule. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal del...