We prove that if A ⊂ Fq\{0} with |A| > Cq 5 6 , then |R(A) ·R(A)| ≥ C′q3, where R(A) = {( a11 a12 a21 a22 ) ∈ SL2(Fq) : a11, a12, a21 ∈ A } . The proof relies on a result, previously established by D. Hart and the author ([3]) which implies that if |A| is much larger than q 3 4 then |{(a11, a12, a21, a22) ∈ A×A×A×A : a11a22 − a12a21 = 1}| = |A|4q−1(1 + o(1)).

ADAM 17 (TNF-α converting enzyme, TACE) is a potential target for cancer therapy, but the small molecule inhibitors reported to date are not specific to this ADAM family member. This membrane-bound metalloproteinase is responsible for ectodomain shedding of pathologically significant substrates including TNF-α and EGFR ligands. The aim of this study was to evaluate the pharmacokinetics, pharmac...

(1) zd = { i √ d 2 if d ≡ 0 (mod 4), −1+i √ d 2 if d ≡ 3 (mod 4). The j-function has the remarkable property that j(zd) is an algebraic integer of degree h(−d), the class number of K = Q(zd). In fact, K(j(zd)) is the Hilbert class field of K [4]. The first few values of j(zd) are: j(z3) = 0, j(z4) = 12 , j(z7) = −153, j(z8) = 20, j(z11) = −323 j(z15) = −191025−85995√5 2 , j(z19) = −963, j(z20) ...

Melanoma associated-A antigens (MAGE-A) are silent in normal tissues except testis. However, they are activated ina variety of different tumors. Thus, their expression is highly specific to cancer cells. Reverse transcription-nested polymerase chain reaction (RT-nPCR) is a highly sensitive technique that has been used successfully for the detection of MAGE genes in tissue samples. The aim of th...

Resistance to targeted tyrosine kinase inhibitors (TKI) remains a challenge for the treatment of myeloid leukemias. Following treatment with TKIs, the bone marrow microenvironment has been found to harbor a small pool of surviving leukemic CD34+ progenitor cells. The long-term survival of these leukemic cells has been attributed, at least in part, to the protective effects of bone marrow stroma...

Targeted monoclonal antibody therapy is an important strategy in cancer therapeutics. Among the most promising characteristics of therapeutic targets are those that modulate the growth and survival of malignant neoplasms and their sensitivity to anticancer therapies. The insulin-like growth factor-I receptor (IGF-IR) is overexpressed in many types of solid and hematopoietic malignancies, and ha...

Mice immunized with recombinant mouse Pneumocystis carinii antigen A12-thioredoxin fusion protein developed an antibody response that recognized P. carinii antigens, as determined by Western blotting and immunofluorescence analysis. Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P. carinii burdens after CD4+ T-cell depletion...

Among the Oji-Cree of northern Ontario, we previously identified a novel variant in the HNF1A gene, namely G319S, that was strongly associated with type 2 diabetes. However, the majority of subjects with diabetes did not have the HNF1A S319 variant, suggesting that there might be other genetic determinants of diabetes susceptibility. In the course of sequencing candidate genes in diabetic subje...