The hepato-intestinal induction of the detoxifying enzymes CYP3A4 and CYP3A5 by the xenosensing pregnane X receptor (PXR) constitutes a key adaptive response to oral drugs and dietary xenobiotics. In contrast to CYP3A4, CYP3A5 is additionally expressed in several, mostly steroidogenic organs, which creates potential for induction-driven disturbances of the steroid homeostasis. Using cell lines ...

Compared with its rodent orthologs, little is known about the chemical specificity of human constitutive androstane receptor (hCAR) and its regulation of hepatic enzyme expression. Phenytoin (PHY), a widely used antiepileptic drug, is a potent inducer of CYP2B6 in primary human hepatocytes, but does not activate human pregnane X receptor (PXR) significantly in cell-based transfection assays at ...

the study of tectonic evolution of the tethyan and se asian regions indicates that these tworegions have each passed through southwardly progressing sequences of similar tectonic events. both regionshave experienced a southward island-arc subduction and back-arc spreading leading to continentaldetachment from gondwanaland, with an earlier southward island arc subduction of palaeotethys (tethyan...

rust caused by phakopsora pachyrhizi syd. is a major constraint to soybean product in asia. early detection and possibilities of controlling plant diseases by the integration of several image processing methods has been the subject of extensive research. the main contribution of this paper is to present different methodologies for quantitatively detecting soybean rust at each stage of disease d...

in this article, the prcsigrnoid avenue to pertroclivai region is introduced and the advantage of such an approach is disusscd. ten patients were operated on by this approach. two illustrative cases are also presented.