X-linked agammaglobulinemia (XLA) is among the most common inborn errors of immunity. The usual clinical phenotype an increased susceptibility to bacterial and enteroviral infections; however, other viral infections, which result in chronic, severe, or recurrent are being increasingly reported XLA. These include respiratory viruses, herpesviruses, hepatotropic more rarely members from astroviru...

PCR: polymerase chain reaction TMP-SMX: trimethoprim-sulfamethoxazole XLA: X-linked agammaglobulinemia INTRODUCTION Helicobacter cinaedi is an unusual cause of cellulitis in immunocompromised patients. The organism is fastidious, and blood cultures are often negative, making the diagnosis challenging, especially in those without systemic signs. We report a case of chronic H cinaedi cellulitis i...

Sentinel mouse seroconversion to infectious agents is critical for laboratory animal facility disease monitoring. We report spontaneous emergence of non-sex-linked agammaglobulinemia with B-cell deficiency and cutaneous Staphylococcus aureus granulomatosis (botryomycosis) in a cohort of related Swiss Webster sentinel mice. Our experience reinforces the importance of immunocompetency validation ...

Normal human peripheral blood lymphocytes were separated on discontinuous gradients of 17-35% bovine serum albumin (BSA) into nine fractions. Three subpopulations of lymphocytes were obtained. One occupies the top third of the gradient (fractions 1-3, 17-23% BSA) and is rich in cells characterized by a high spontaneous rate of DNA synthesis and by the ability to give rise to colony-forming unit...