PURPOSE This study explores the potential of the simvastatin to ameliorate inflammation and infection in open infected skin wounds of rats. METHODS Fourteen Wistar rats weighing 285 +/- 12g were used. The study was done in a group whose open infected skin wounds were treated with topical application of simvastatin microemulsion (SIM, n=7) and a second group with wounds treated with saline 0.9...

Pseudomonas aeruginosa infections of wounds in clinical settings are major complications whose outcomes are influenced by host responses that are not completely understood. Herein we evaluated transcriptomic changes of wounds as they counter P. aeruginosa infection-first active infection, and then chronic biofilm infection. We used the dermal full-thickness, rabbit ear excisional wound model. W...

Quantitatively, wounds harboring bacteria that exceed 105 colony-forming units per gram are considered infected wounds. There are acute wounds and chronic wounds, and the approach to controlling the infection is similar. Although the granulating bed may be avascular, systemic anti-infectives are employed adjunctively to circumvent systemic infection. The main armamentarium of the attack is the ...

Infection is a major factor that postpones wound healing specially in traumatic wounds. Many reports indicate important role of washing solutions on preventing wound infections. Tap water has been used for centuries as a wound cleanser without evidence of adverse effects or associated infection risk. Normal sterile saline is also regarded as the most appropriate and preferred cleansing solution...

OBJECTIVE The aim of this study was to determine the rate of infection at which it is cost-effective to treat dog bite wounds with antibiotics. METHODS Our study was composed of two parts. First we performed a randomized, double-blind controlled trial (RCT) to compare the infection rates of dog bite wounds in patients given amoxicillin-clavulanic acid versus placebo. Subjects were immunocompe...

INTRODUCTION This case series aims to study the effectiveness of Renasys-GO™ negative pressure wound therapy system in the healing of diabetic lower limb ulcers. MATERIALS AND METHODS An electronic vacuum pump (Renasys-GO™, Smith & Nephew GmbH) was used to apply negative pressure wound therapy on wounds, with pressure settings determined according to clinical indication. Changes in wound dime...