Since the discovery of microemulsions, they have attained increasing significance both in basic research and in industry. Due to their unique properties, namely, ultralow interfacial tension, large interfacial area, thermodynamic stability and the ability to solubilize otherwise immiscible liquids, uses and applications of microemulsions have been numerous. The objective of this review is to pr...

( * ) Notice: Subject to any disclaimer, the term of this W0 WO 91/10645 7/1991 patent is extended or adjusted under 35 W0 WO 92/08707 5/1992 U'S'C~ 154(1)) by 0 days' W0 WO 92/21017 11/1992 W0 WO 93/05049 3/1993 (21) Appl. N0.: 10/737,486 W0 WO 93/06868 4/1993 W0 WO 93/12097 6/1993 (22) Filed: Dec. 16, 2003 W0 WO 93/14093 7/1993 W0 WO 94/15925 7/1994 (65) Prior Publication Data W0 WO 94/26315 ...

Ionic liquids (ILs), 1-butyl-3-methylimidazolium tetrafluoroborate (bmimBF4), were substituted for polar water and formed nonaqueous microemulsions with toluene by the aid of nonionic surfactant TX-100. The phase behavior of the ternary system was investigated, and microregions of bmimBF4-in-toluene (IL/O), bicontinuous, and toluene-in-bmimBF4 (O/IL) were identified by traditional electrical co...

As models for the effects of unesterified cholesterol (UC) on the lipid organization of low density lipoprotein (LDL), microemulsions containing either egg yolk phosphatidylcholine (EYPC) or dimyristoyl phosphatidylcholine (DMPC) as the surface component, cholesteryl oleate (CO) as the core component, and varying amounts of unesterified cholesterol were prepared by sonication. Gel filtration ch...

The bactericidal properties of myristic acid and curcumin were revealed in a number of studies. However, whether curcumin-loaded myristic acid microemulsions can be used to inhibit Staphylococcus epidermidis, which causes nosocomial infections, has not been reported. Our aim was to develop curcumin-loaded myristic acid microemulsions to inhibit S. epidermidis on the skin. The interfacial tensio...

Microemulsions of negatively charged (sodium bis(2-ethylhexyl)sulfosuccinate, AOT) and positively charged (dodecylmethylbutylammonium bromide and benzyldimethylhexadecylammonium chloride) surfactants were studied below and above the percolation thresholds by electrical conductivity, near-infrared absorption, and thermal lens spectrometry. It was found that the AOT microemulsions undergo percola...

HYPOTHESIS The formation, stability and structural properties of normal liquid phase microemulsions, stabilized by hydrocarbon surfactants, comprising water and hydrocarbon oils can be interpreted in terms of the film bending rigidity (energy) model. Here, this model is tested for unusual water-in-CO2 (w/c) microemulsions, formed at high pressure with supercritical CO2 (sc-CO2) as a solvent and...

Microemulsions have received great attention for applications in transdermal drug delivery. The use of curcumin for treating various skin diseases like scleroderma, psoriasis, and skin cancer was extensively reported. The solubility of curcumin in various oils, surfactants, and cosurfactants was studied herein in order to find the optimal components for a transdermal delivery vehicle. Microemul...

PURPOSE To establish a novel formulation tumor-targeted drug carrier of lipophilic antitumor antibiotics, aclacinomycin A (ACM), folate-linked microemulsions were prepared and investigated both in vitro and in vivo. EXPERIMENTAL DESIGN Three kinds of folate-linked microemulsions with different polyethylene glycol (PEG) chain lengths loading ACM were formulated with 0.24 mol% folate-PEG(2000)-...