in recent years many researchers have been focused on interaction of small molecules with dna. dna is generally the primary intracellular of anticancer drugs, so the interaction between small molecules and dna can cause dna damage in cancer cells, blocking the division of cancer cells and resulting in cell death. the flavonoids are a large group of polyphenolic natural products that are widely ...

Introduction: Cardiotoxicity is an unavoidable complication after chemotherapy. The present study investigated the effect of 12 weeks of aerobic exercise (high-intensity interval training or moderate-intensity continuous training) with and without blood flow restriction on some anthropometric indices in women with breast cancer who had chemotherapy-induced cardiotoxicity. Methods: Twenty breas...

Introduction: Inflammation in the brain is known as neuroinflammation and increases TNF-α (Tumor necrosis factor alpha) secretion and activates the TLR4 (Toll-like receptor 4) pathway. The aim of this study was to evaluate the effect of 4 weeks preconditioning with high intensity intermittent training (HIIT) and moderate intensity training (MICT) on TNF-α and TLR4 levels in male Wistar rats. M...

Objectives We aimed to investigate the effect of low and moderate intensity aerobic exercises on sleep quality of older adults.  Methods & Materials The research method was quasi-experimental with pre-test and post-test design. The statistical sample included 45 volunteer elderly men aged 60-70 years who were divided randomly into two experimental groups (aerobic exercise with low and mod...

Introduction: Exploratory behaviors in rodents are an indicator of anxiety behaviors. In the present study, the combined effect of aerobic exercise with different intensities and inhibition of the glutamate system on exploratory behavior in rats was investigated. Materials and Methods: In this experimental study, 80 male Wistar rats were randomly divided into 10 groups including control, diazep...