Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus with aromatic groups were tolerated, with the IC₅₀ values between 1.29 and 12.8...

After advent of Islam especially through and after the reign of Abbasid caliphs; interest of scientists and engineers wasdrawn towards the” mechanical or ingenious devices”. The wise jar was originally designed by Ahmad ibnMüsä, thefamous Iranian scientist who lived in the 5th century A.H.(9th A.D). It consists of a jar with a mechanically intelligentmechanism inside, which is capable of separa...

The compounds synthesized in this research were designed with the goal of establishing a new paradigm for mixed-base-pair DNA sequence-specific recognition. The design scheme starts with a cell-permeable heterocyclic cation that binds to AT base pair sites in the DNA minor groove. Modifications were introduced in the original compound to include an H-bond accepting group to specifically recogni...

Epigenetic modifications, such as DNA methylation and histone modifications, are dynamically altered predominantly in paternal pronuclei soon after fertilization. To identify which histone modifications are required for early embryonic development, we utilized histone K-M mutants, which prevent endogenous histone methylation at the mutated site. We prepared four single K-M mutants for histone H...

In this submission to MIREX’07, we implement various modifications to the Algorithm G1C by Elias Pampalk which ranked first in last year’s MIREX AudioSim task. Although each of the modifications showed only minor effects in our experiments, their combination constantly outperformed the original algorithm in our automated tests. Therefore, we consider it worth submitting the resulting algorithm ...

A method for compressing large binary images is proposed for applications where spatial access to the image is required. The proposed method is a two-stage combination of forward-adaptive modeling and backward-adaptive context based compression with re-initialization of statistics. The method improves compression performance significantly in comparison to a straightforward combination of JBIG a...