abstract objective: the previous studies indicated that the tlrs especially toll-like receptor 4) tlr4 (are involved in the process of diabetes. the aim of the present research was to investigate the time course expression pattern of tlr4-a main component of innate immune system- in mrna levels in the heart tissue of diabetic male wistar rats. materials and methods: in this research, adult wist...

the effect of hypericin on the expression of morphine-induced conditioned place preference (cpp) was investigated and compared with the effect of the synthetic antidepressants. the cpp paradigms took place over six days using an unbiased procedure. the results demonstrate that intra-peritoneal (ip) injection of morphine sulfate (2.5, 5 and 10 mg/kg) significantly induce the cpp in rat. intra-pe...

introduction: there is no comprehensive study on the effect of folate on food intake therefore the present study was carried out to determine the effect of folate supplementation on serum concentrations of leptin and grehlin and food intake in male wistar rats. methods: the study was carried out for 42 days during which the animals were weighed weekly their food and water intakes were measured ...

Laboratory animals, including rats, play an important role in biomedical research and advances. The human care and management of these animals is an ongoing concern. Since, Trichosomoides infections in rat colonies can interfere with research protocols it is important to know rate of infection and pathology of the infection in the animals used in experimental studies. 275 rats were eviscerated ...

We report on five 6-month experiments during which five colonies of four male and four female rats were exposed to psychosocial stress. Monthly blood pressure measurements by a tail-cuff method showed a modest (10 mm Hg) increase in two studies using Sprague-Dawley rats. In two further studies using the more aggressive Long-Evans strain, terminal direct carotid arterial pressures were taken as ...

Radioprotective effects of ethanolic extracts Gongronema latifolium leaf against radiation induced oxidative stress in Wistar albino Rats

Aldosterone and other mineralocorticoids increase citrate synthase activity in the kidney and enhance renal sodium reabsorption, but it is unclear whether the increased citrate synthase activity is involved in renal sodium transport. We used the Wistar-Furth rat, an inbred strain found to be deficient in renal citrate synthase activity, as an experimental model to investigate this issue. We con...

Wistar-Furth rats have been shown to be resistant to mineralocorticoid-salt hypertension, but the mechanism for this resistance is unknown. In the current experiments, adult male Wistar and Wistar-Furth rats were given a subcutaneous aldosterone infusion (0.15 microgram/hr) for 4 weeks, and changes in blood pressure and vascular reactivity were studied. Rats received a 1% NaCl, 0.2% KCl solutio...

Hyperthermic shock is a thermoregulatory disorder that affects living organisms that are acutely or chronically exposed to high temperatures or when performing intense physical activity in a hot environment. In this paper, we will show the changes embodied in hyperthermic shock caused by multiple injuries to vital organs in Wistar rats that were suddenly exposed to high temperatures of up to 41...

BACKGROUND Exercise can change cellular structure and connectivity (neurogenesis or synaptogenesis), causing alterations in both behavior and working memory. The aim of this study was to evaluate the effect of exercise on working memory and hippocampal neurogenesis in adult male Wistar rats using a T-maze test. METHODS An experimental design with two groups was developed: the experimental gro...