A marine arenicin-3 derivative, N4, displayed potent antibacterial activity against Gram-negative bacteria, but its antibacterial mode of action remains elusive. The mechanism of action of N4 against pathogenic Escherichia coli was first researched by combined cytological and transcriptomic techniques in this study. The N4 peptide permeabilized the outer membrane within 1 min, disrupted the pla...

In this paper we re-examine the alkali dependence of the fraction of four-coordinated borons (N4) in two series of glasses: alkali borates (0·4M2O.B2O3) and mixed lithium caesium borates (0·4(xLi2O+(1-x)Cs2O). B2O3). High field B MAS-NMR experiments were performed to maximise the accuracy of the present results. We found no evidence for an alkali dependence on N4 in either system. In each case ...

Two bacteriophages, DSS3Phi2 and EE36Phi1, which infect marine roseobacters Silicibacter pomeroyi DSS-3 and Sulfitobacter sp. EE-36, respectively, were isolated from Baltimore Inner Harbor water. These two roseophages resemble bacteriophage N4, a large, short-tailed phage infecting Escherichia coli K12, in terms of their morphology and genomic structure. The full genome sequences of DSS3Phi2 an...

The author uses irrationality and linear independence measures for certain algebraic numbers to derive explicit upper bounds for the solutions of related norm form equations. The Lenstra-Lenstra-Lovász lattice basis reduction algorithm is then utilized to show that the integer solutions to NK/Q(x 4 √ N4 − 1 + y 4 √ N4 + 1 + z) = ±1 (where K = Q( 4 √ N4 − 1, 4 √ N4 + 1)) are given by (x, y, z) =...

We estimate analytically the critical coupling separating the weak and the strong coupling regime in 4D simplicial quantum gravity to be located at kcrit 2 ≃ 1.3093. By carrying out a detailed geometrical analysis of the strong coupling phase we argue that the distribution of dynamical triangulations with singular vertices, dominating in such a regime, is characterized by distinct sub-dominatin...

Four guanidine derivatives of N4,N9-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18 unsaturated chains, N1,N12-diamidino-N4,N9-dioleoylspermine and N1,N12-diamidino-N4-linoleoyl-N9-oleoylspermine, were more efficient in terms of GFP expression reduction compared ...

The purpose of this study was to develop an efficient way to synthesize (99m)Tc-O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-tyrosine ((99m)Tc-N4-Tyrosine), a novel amino acid-based radiotracer, and evaluate its potential in breast cancer gamma imaging. Precursor N4-Tyrosine was synthesized using a 5-step procedure, and its total synthesis yield was 38%. It was successfully labeled with (9...

Samples were selected at two different times. At first sampling, populations were from staff nurses who were just classified as N1, N2, N3 and N4 level according to the clinical ladder system. Samples were randomly selected from N1 and N2, N3 level subjects and N4 subjects were all selected as samples. Sample sizes were 416, and 321 questionnaires returned were usable. At second sampling, popul...

The goal of this investigation is to study the effect of wing sweep angle on the horizontal wing-body- tail configurations in subsonic flow. For this purpose, a series of wind tunnel tests were conducted on a model having a moveable horizontal tail and a wing planform with different sweep angles. Tests were performed at different tail deflection angles. Static surface pressure distribution over...