Polycomb repressive complex 2 (PRC2), which is responsible for the trimethylation of H3K27 (H3K27me3), plays a part in tumorigenesis, development and/or maintenance of adult tissue specificity. The pivotal role of PRC2 in cancer makes it a therapeutic target for epigenetic cancer therapy. However, natural compounds targeting the enhancer of zeste homolog 2 (EZH2) - embryonic ectoderm developmen...

Signal transducers and activators of transcription 1 (STAT1) transduces signals from cytokines and growth factors, particularly IFN-γ, and regulates expression of genes involved in cell survival/death, proliferation, and migration. STAT1 is activated through phosphorylation on its tyrosine 701 by JAKs and is inactivated through dephosphorylation by tyrosine phosphatases. We discovered a natural...

The basic objective of this work was to identify and estimate the active constituents present in the herb Coldenia procumbens Linn. A survey of literature showed that the plant has not been exploited properly and remains a silent drug in herbal medicine. In this work, the coumestan derivative wedelolactone was identified in the methanolic extract of the plant by TLC. The concentration of wedelo...

Eclipta alba can be found growing wild in fallow lands of Bangladesh where it is considered as a weed by farmers. Traditional medicinal systems of the Indian subcontinent countries as well as tribal practitioners consider the plant to have diverse medicinal values and use it commonly for treatment of gastrointestinal disorders, respiratory tract disorders (including asthma), fever, hair loss an...

Eclipta alba Hassk ( Asteraceae ) having important role in the traditional Ayurvedic, Unani systems of holistic health and herbal medicine of the east. Its main active constituents are wedelolactone, demethylwedelolactone . The important pharmacological activities are Hepatoprotective, Antimicrobial, Antinociceptive, Anti-inflammatory, Analgesic, Immunomodulatory, Antiviral and C.N.S. activity....

Despite the rigorous global efforts to control SARS-CoV-2 transmission, it continues pose a serious threat humans with frequent emergence of new variants. Thus, robust therapeutics combat virus are desperate need. The spike (S) protein is an important target as mediates entry inside host cells, which initiated by binding receptor-binding domain (RBD) its cognate receptor, angiotensin-converting...

BACKGROUND Wedelia chinensis is traditionally used as a hepatoprotective herb in Taiwan. The aim of this study was to evaluate the neuroprotective potential of W. chinensis. METHODS An ethyl acetate extract of W. chinensis (EAW) was prepared and analyzed by HPLC. The neuroprotective potential of EAW was assessed by tert-butylhydroperoxide (t-BHP)-induced damage in PC12 cells and D-galactose-i...

Methamphetamine (METH) is an amphetamine-typed stimulant drug that is increasingly being abused worldwide. Previous studies have shown that METH toxicity is systemic, especially targeting dopaminergic neurons in the central nervous system (CNS). However, the role of neuroinflammation in METH neurotoxicity remains unclear. We hypothesized that Toll-like receptor 4 (TLR4) and Caspase-11 are invol...