Context Weaver is a platform that simplifies writing of context-aware applications. All providers of context information registered with Context Weaver provide data to applications through a simple, uniform interface. Applications access data sources not by naming particular providers of the data, but by describing the kind of data they need. Context Weaver responds with providers of context in...

The weaver mutation corresponds to a substitution of glycine to serine in the H5 region of a G protein-gated inwardly rectifying K+ channel gene (GIRK2). By studying mutant GIRK2 weaver homomultimeric channels and heteromultimeric channels comprised of GIRK2 weaver and GIRK1 in Xenopus oocytes, we found that GIRK2 weaver homomultimeric channels lose their selectivity for K+ ions, giving rise to...

We explore the relationship between emotional well-being and economic freedom. Using data for a sample of 12 countries from wave 2 of the World Value Survey (WVS) and the Economic Freedom of the World (EFW) index, we find that people living in more economically free societies are more likely to report the presence of positive affect and absence of negative affect. Specifically, people who live ...

The weaver mutation impairs migration of the cerebellar granular neurons and induces neuronal death during the first two weeks of postnatal life. To elucidate the molecular mechanisms for the impaired neuronal migration, we investigated the rescue mechanisms of the weaver (wv/wv) granule neurons in vitro. We found that Fab2 fragments of antibodies against a neurite outgrowth domain of the B2 ch...

The dopamine system in weaver mutant mice (BGCBA-AwmJ/A background) was studied. Dopamine was 27% lower in the olfactory tubercle, 77% lower in the frontal cortex, and 75% lower in the striatum of 6-month-old weaver mice compared to control mice of the same age. Norepinephrine and serotonin were not lower in these brain areas. Tyrosine hydroxylase activity in the striatum was measured with a ra...

In the neurological mutant mouse weaver, granule cell precursors proliferate normally in the external germinal layer of the cerebellar cortex, but fail to differentiate. Granule neurons purified from weaver cerebella have greatly reduced G protein-activated inwardly rectifying K+ currents; instead, they display a constitutive Na+ conductance. Expression of the weaver GIRK2 channel in oocytes co...

To study the regulation of glial-guided neuronal migration, we have analyzed the behavior of cerebellar granule neurons purified from the homozygous weaver (wv/wv) B6CBA-w mouse, an autosomal recessive genetic mutation that suffers a failure of granule cell migration along Bergmann glial processes (Rakic and Sidman, 1973a, b; Rezai and Yoon, 1972), on the processes of astroglia purified from ho...

Whereas parents typically believe that their children increase their happiness (e.g., Eibach & Mock 2011), decades of research have found little support for this contention (Dolan et al. 2008). In a recent paper, Nelson et al. (2013) address the issue with analyses of the World Values Survey (WVS; 2006) and an experience-sampling dataset (Carstensten et al. 2010). Though the authors carefully a...