نتایج جستجو برای: warfarin

تعداد نتایج: 9538  

Journal: :research in molecular medicine 0
reyhaneh kameli biology department, islamic azad university of pharmaceutical sciences, tehran, iran mandana hasanzad medical sciences research center, tehran medical branch, islamic azad university, tehran, iran zahra tahmasebi fard department of biology, roudehen branch, islamic azad university, roudehen, iran mojgan babanejad cardiogenetics research center, shahid rajaie cardiovascular medical & research center, tehran, iran mahdieh imeni biology department, islamic azad university of pharmaceutical sciences, tehran, iran lotfollah feizi barnaji cardiogenetics research center, shahid rajaie cardiovascular medical & research center, tehran, iran

background: warfarin is a common anticoagulant drug that has a narrow therapeutic index; higher dose causes excessive bleeding and lower dose leads to cerebrovascular clotting and stroke in patients. genetic factors that have been associated with warfarin response are the genes of cytochrome p450 2c9 (cyp2c9), which metabolize the more active s-enantiomer of warfarin, and vitamin k epoxide redu...

The requirement of varying doses of warfarin for different individuals can be explained by environmental and genetic factors. We evaluated the frequency of vitamin K epoxide reductase complex subunit 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) variants together with patientdemographic characteristics and investigated their association with warfarin dose requirement with the ob...

Journal: :jentashapir journal of health research 0
zahra tolou-ghamari isfahan urology and kidney transplantation research center, alzahra research centers, isfahan university of medical sciences, isfahan, ir iran; isfahan urology and kidney transplantation research center, alzahra research centers, isfahan university of medical sciences, isfahan, ir iran hamid mazdak department of urology, alzahra hospital, faculty of medicine, isfahan university of medical sciences, isfahan, ir iran

conclusions race, age, body surface area, chronic kidney disease, cyp2c9*3 level, and vkorc1 variants could affect the dose of warfarin. to administer the proper doses of warfarin, patients and physicians might achieve the best results with the pharmacologist proficient anticoagulation database and recommended continuation program. owing to its’ unpredictability, caution must be taken when pres...

An important complication of chemotherapy is thromboembolic events that can occur during treatment course. In this way, Warfarin can be used as an efficient prophylactic agent to prevent these complications. Although bleeding is a common adverse effect of Warfarin, eosinophilia is a rare side effect of this drug. We have reported a 5-year-old boy with Burkitt lymphoma who underwent chemotherapy...

The requirement of varying doses of warfarin for different individuals can be explained by environmental and genetic factors. We evaluated the frequency of vitamin K epoxide reductase complex subunit 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) variants together with patientdemographic characteristics and investigated their association with warfarin dose requirement with the ob...

A high prevalence of genetic polymorphisms increases sensitivity to warfarin therapy. In this study, we investigated 47 patients with effective long-term therapy by warfarin well-controlled by monitoring of International Normalised Ratio (INR). All patients were tested for gene polymorphisms VKORC1, CYP2C9*C2, and CYP2C9*C3, which were used for a dose calculation employing a program www.Warfari...

Background and Aims: Warfarin is an anticoagulant agent used for many years in treating various clinical conditions such as thromboembolisms in cardiovascular disease. Some patients require different doses of warfarin to reach the therapeutic international normalized ratio ratio. These patients have specific demographic characteristics. Genetic polymorphisms in specific genes have been reported...

Behnam Askari, esmat khaleqsefat, Hamid Soraya, Mohammad Khalaj-Kondori, Morteza Jabbarpour bonyadi,

Warfarin is a commonly-prescribed anticoagulant used to treat and prevent thromboembolic events. The requirement for varying doses of warfarin depends on genetic and environmental components. In this study, the frequency of two single-nucleotide polymorphic variants of the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene (1173 C>T (rs9934438) and 3730 G>A (rs7294)) and its correlatio...

Introduction: Using artificial intelligence tools in pharmacogenomics is one of the latest bioinformatics research fields. One of the most important drugs that determining its initial therapeutic dose is difficult is the anticoagulant warfarin. Warfarin is an oral anticoagulant that, due to its narrow therapeutic window and complex interrelationships of individual factors, the selection of its ...

A high prevalence of genetic polymorphisms increases sensitivity to warfarin therapy. In this study, we investigated 47 patients with effective long-term therapy by warfarin well-controlled by monitoring of International Normalised Ratio (INR). All patients were tested for gene polymorphisms VKORC1, CYP2C9*C2, and CYP2C9*C3, which were used for a dose calculation employing a program www.Warfari...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید