Vulvar Paget 'disease is the most common site of extramammary Paget's disease (EMPD). The disease frequently associated with the underlying invasive skin adnexal carcinoma or representing the migration of underlying internal malignancy, especially anorectal and genitourinary cancer, but the coexisting with primary breast cancer is rare. Herein, the authors report a case of a 46-year-old Thai wo...

abstract: introduction: the prevalence of adnexal tumour has been reported to vary between one in eight thousands to 2.3% of pregnancies according to investigational techniques administered. broader use of ultrasonography in pregnancy and the increasing rate of caesarean section (c-section) could be expected to lead to the diagnosis of more adnexal tumours compared to previous studies. aim and ...

OBJECTIVE To demonstrate a unique case report about late and isolated vulvar metastasis of sigmoid adeno-carcinoma with review of the literature. MATERIAL-METHOD 57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metasta...

AIM The gene for familial cylindromatosis (CYLD) has been localised to chromosome 16q, and has recently been cloned. Loss of heterozygosity (LOH) at 16q has also been demonstrated in sporadic cylindromas. The aim of this study was to investigate whether CYLD plays a role in the development of other skin appendage tumours. METHODS A total of 55 cases of skin adnexal tumours, comprising 12 diff...

BACKGROUND: Reports of histological types of orbital and adnexal tumours are few in the West African Sub-region and non-existent in Ghana. OBJECTIVE: This study was to determine and report the histological types of orbital and adnexal tumours seen in the eye unit in Korle-bu Teaching Hospital METHODS:This was a retrospective study of orbital and adnexal tumours in a referral orbit and oculoplas...

The Thomsen-Friedenreich (T) antigen is the core disaccharide of cancer-associated carbohydrates, whose expression allegedly correlates with the prognosis of some carcinomas. We studied the expression of the T antigen and its precursor (Tn) with monoclonal antibodies in formalin-fixed specimens of normal skin and various benign cutaneous tumours and inflammatory lesions (n: 105). In normal skin...

Malignant melanomas of the vulva are rare tumours which constitute only 5-10% of all vulvar cancers but are the second commonest vulvar malignancy after squamous carcinomas. Almost all vulvar naevi are of the junctional type from which melanomas are believed to arise and this may explain why in women, 3-5% of melanomas occur in the vulva though it occupies only 1-2% of the body surface area. Vu...

AIMS To report five malignant trichogenic tumours arising in longstanding, previously benign adnexal neoplasms through malignant transformation. Malignant trichogenic adnexal tumours are extremely rare neoplasms. METHODS AND RESULTS The patients were between 55 years and 79 years of age. Three of the tumours were located on the arms, two on the face. Three of our patients had a history of chr...

Background: Cutaneous appendageal tumours can arise from either the eccrine, apocrine, hair follicles or the sebaceous glands. Majority of the tumours are benign. Final diagnosis requires a good clinical as well as histpathological correlation. The aim of the present study was to assess the clinicopathological characteristic of these tumours. Materials & Methods: The present study was a retro-p...