In neuroimaging, voxel based morphometry (VBM) has been a valuable tool of identifying brain-wide differences between populations. One of the key elements of VBM is to define a space for voxelwise comparisons. However, errors in this mapping to common space and variations of brain morphology, both natural and pathologic can result in false positives. In this work we explore a new framework, whe...

At its simplest, voxel-based morphometry (VBM) involves a voxel-wise comparison of the local concentration of gray matter between two groups of subjects. The procedure is relatively straightforward and involves spatially normalizing high-resolution images from all the subjects in the study into the same stereotactic space. This is followed by segmenting the gray matter from the spatially normal...

Voxel-Based MR-Morphometry and Diffusion Tensor Imaging: Basics and Applicability in Clinical Neurology. The potential and clinical options are presented which originate from the clinical application of computer-based magnetic resonance imaging (MRI) techniques such as voxel-based morphometry (VBM) to human brain grey and white matters as

Geometric information obtained from MRI is widely used for various applications, including voxel-based morphometry brain volume measurement, radiation therapy planning, and MRI-guided therapy.

Background: The hippocampus and corpus callosum have been shown to be vulnerable in head injury. Various neuroimaging modalities and quantitative measurement techniques have been employed to investigate pathological changes in these structures. Cognitive and behavioural deficiencies have also been well documented in head injury. Aims: The aim of this research project was to investigate structur...