Objective: Recent studies demonstrated changes of serum and plasma amyloid ß-protein (Aβ) levels in patients with depression. Although the change of serum levels of Aβ has been suggested as a risk factor for future onset of Alzheimer’s disease, the relationship between Aβ levels and treatment response in patients with depression is still unclear. Our objective of this study is to assess whether...

Introduction: Major depressive disorder is a common mental condition associated with substantial morbidity and economic burden. Approved by the FDA in September 2013 for treatment of episodes of major depressive disorder, Vortioxetine is one of the newer options available in this important area of therapeutics. Materials and methods: A comprehensive literature search (PubMed, the Cochrane libr...

Antidepressants often disrupt sleep. Vortioxetine, a multimodal antidepressant acting through serotonin (5-HT) transporter (SERT) inhibition, 5-HT3, 5-HT7 and 5-HT1D receptor antagonism, 5-HT1B receptor partial agonism, and 5-HT1A receptor agonism, had fewer incidences of sleep-related adverse events reported in depressed patients. In the accompanying paper a polysomnographic electroencephalogr...

Since poor circadian synchrony and cognitive dysfunction have been linked to affective disorders, antidepressants that target key 5-HT (serotonin) receptor subtypes involved in circadian rhythm and cognitive regulation may have therapeutic utility. Vortioxetine is a multimodal antidepressant that inhibits 5-HT1D, 5-HT3, 5-HT7 receptor activity, 5-HT reuptake, and enhances the activity of 5-HT1A...

Objective: Recent studies demonstrated changes of serum and plasma amyloid ß-protein (Aβ) levels in patients with depression. Although the change of serum levels of Aβ has been suggested as a risk factor for future onset of Alzheimer’s disease, the relationship between Aβ levels and treatment response in patients with depression is still unclear. Our objective of this study is to assess whether...

Vortioxetine is approved for the treatment of adults with major depressive disorder. This open-label extension (OLE) study evaluated the safety and tolerability of vortioxetine in the long-term treatment of major depressive disorder patients, as well as evaluated its effectiveness using measures of depression, anxiety, and overall functioning. This was a 52-week, flexible-dose, OLE study in pat...

Objective: Recent studies demonstrated changes of serum and plasma amyloid ß-protein (Aβ) levels in patients with depression. Although the change of serum levels of Aβ has been suggested as a risk factor for future onset of Alzheimer’s disease, the relationship between Aβ levels and treatment response in patients with depression is still unclear. Our objective of this study is to assess whether...

BACKGROUND Vortioxetine was approved by the U.S. Food and Drug Administration (FDA) in September 2013 for treating major depressive disorder (MDD). Thus far, a number of randomized, double-blind, placebo-controlled clinical trials (RCTs) of vortioxetine have been conducted in patients with MDD. We performed a meta-analysis to increase the statistical power of these studies and enhance our curre...

Depression symptoms resulting from cognitive function impairment are emphasized by both DSM5 and ICD-10 diagnostic criteria for major depressive disorder and depressive episodes. Nonetheless, the role of cognitive dysfunctions seem to remain underestimated in case of depressive disorders, thus they are rarely perceived as therapeutic target. Vortioxetine is a relatively new, multi-functional ag...

introduction: major depressive disorder is a common mental condition associated with substantial morbidity and economic burden. approved by the fda in september 2013 for treatment of episodes of major depressive disorder, vortioxetine is one of the newer options available in this important area of therapeutics. materials and methods: a comprehensive literature search (pubmed, the cochrane libra...