The human vitreous contains primarily water, but also contains proteins which have yet to be fully characterized. To gain insight into the four vitreous substructures and their potential functions, we isolated and analyzed the vitreous protein profiles of three non-diseased human eyes. The four analyzed substructures were the anterior hyaloid, the vitreous cortex, the vitreous core, and the vit...

Immunochemical analysis of human and bovine vitreous has shown that these structures contain many serum proteins. One of the alpha glolmlins appears to he present in human vitreous in concentrations higher than the serum itself. Pooled human vitreous revealed a precipitating antibody to an extracellular streptococcal antigen. With the most potent antisera available, human vitreous was shown to ...

A series of 54 non-myopic aphakic eyes with no signs of posterior vitreous detachment and 63 non-myopic aphakic eyes with various stages of posterior vitreous detachment was followed-up for a period of 6 months to 6 years. Over half of the eyes with no vitreous detachment when first examined developed various stages of posterior vitreous detachment during the follow-up period; in 10 eyes this w...

PURPOSE We aimed to establish a novel screening system for identifying potential therapeutic agents for treating proliferative vitreoretinal diseases (PVDs). In this study, we focused on vitreous explants from chicken embryos and evaluated the usefulness of quantitatively analyzing the effects of potential candidates on cell-mediated vitreous contraction, which leads to blindness in PVDs. MET...