The effects of thiamine (vitamin B1) on the level of spontaneous or radiation-induced genetic changes in human lymphocytes in vitro were studied. Cultured lymphocytes were exposed to increasing concentrations of thiamine (0-500 microg/ml) and irradiated with X-rays. The DNA damage was estimated as the frequency of micronuclei and apoptotic or necrotic morphological changes in fixed cells. The r...

Vitamin B1 is a watersoluble vitamin. It consists out of a pyrimidineand a thiazol ring, which are synthesized independently and linked afterwards.Vitamin B1 is de novo produced by many plants and microorganisms. Humans and animals have to take it up by nutrition. They are only able to do the phosphorylation reaction of the thiamin molecule. Thiamin is found free and as mono-, diand triphosphat...

THE influence of vitamin B1 on the vaginal contents of the mature rat has been examined with a view to using it as a criterion for the assay of that factor. Evans & Bishop [1922] showed that in the absence6f vitamin 'B' from the diet, the normal cycle of changes in the contents of the vagina was upset. No keratinized cells were found and leucocytes with some nucleated epithelial cells were foun...

BACKGROUND & OBJECTIVE The premenstrual syndrome (PMS) is a series of physical, mental, and behavioral symptoms with various severities, and disturbs social and personal relationships. The syndrome appears during luteal phase of the menstrual cycle and is a common disorder of reproductive age. Different treatments have been introduced for the syndrome due to its unknown complicated causes. Vita...

In a paper dealing with the nutrition of the propionic-acid bacteria Wood, Andersen, and Werkman (1938) report that one species Propionibacterium pentosaceum (49W), can be "trained" to grow as well in the absence of vitamin B1 as in its presence. Their data show that adaptation occurred after continuous serial transfer in an ammonium sulfate medium containing only ether extract of yeast extract...

DtmING A STUDY concerning the role of vitamin B1, in diabetes (1), it was noted that a number of cases in this study failed to excrete more than 10 gig. of a 50Lg. intramuscular load dose of the vitamin. All of these patients had a history of liver disease or some form of hepatic insufficiency. The storage of vitamin B1, by the liver has been studied extensively by Meyer et at. (2) and by Glass...

To explore the effect of vitamin B1 on Diabetic Peripheral Neuropathy (DPN) and its mechanism for providing a theoretical basis for clinical prevention and effective treatment of diabetic neuropathy. 40 SD male rats were randomly divided into four groups (n=10/group) and they were normal control (NC) group, Diabetes Mellitus (DM) group, diabetic peripheral neuropathy (DPN) group and vitamin B1 ...

MOST of the previous work on the distribution of vitamin B in fruits was carried out before the differentiation of the complex into the antineuritic vitamin B1 and the antidermatitis vitamin B2, and as a rule the results of the older experiments give only rough indications of the presence of both constituents of the complex. These have been summarised by Sherman and Smith [1931]. In the work de...