B12 Deficiency, Zouë Lloyd-Wright, 1 Anne-Mette Hvas, Jan Møller, Tom A.B. Sanders, and Ebba Nexø ( Nutrition Food & Health Research Centre, King’s College London, Franklin-Wilkins Bldg., 150 Stamford St., Waterloo, London SE1 9NN, United Kingdom; 2 Department of Clinical Biochemistry, AKH, Aarhus University Hospital, DK8000 Aarhus C, Denmark; 3 Department of Clinical Biochemistry, SKS, Aarhus ...

Vitamin B12 Deficiency, Ebba Nexo, 1* Anna-Lisa Christensen, Anne-Mette Hvas, Torben E. Petersen, and Sergey N. Fedosov ( Department of Clinical Biochemistry, Aarhus University Hospital, DK-8000 Aarhus C, Denmark; 2 The Laboratory for Protein Chemistry, University of Aarhus, DK-8000 Aarhus C, Denmark; * address correspondence to this author at: Department of Clinical Biochemistry, AKH, Aarhus U...

Participants from DPP/DPPOS were assigned to placebo (n=1082) or metformin (n=1073) for 3.2 years, followed by metformin in the metformin group for 9 years. Metformin use was associated with increased risk of vitamin B12 deficiency.

Two elderly patients with vitamin B12 deficiency were found to have low immunoglobulin levels. These returned to normal on treatment with vitamin B12.

We confirm a decrease in cobalamins during pregnancy, and report that the active part of cobalamins (holotranscobalamin, holoTC) remains unchanged. The decrease in cobalamins is explained by a decreased holohaptocorrin (holoHC), suggesting that holoTC rather than cobalamins should be used as a marker of vitamin B12 deficiency during pregnancy.

A comparative study was done to determine the profile of vitamin B12 and folate status in Malaysians during two different periods. For the period of 1987/88, we analysed a total of 9,162 cases (inpatients) referred for vitamin B12 estimation and 10,290 cases for folate estimation. We found that 2.6% were vitamin B12 deficient and 31.2% were folate deficient. For the period of 1992/93, of the 9,...

V itamin B-12 is a cofactor for 2 enzymes. In the cytoplasm, methionine synthase requires vitamin B-12 in the form of methylcobalamin and catalyzes the conversion of homocysteine to methi-onine by transfer of a methyl group from methyltet-rahydrofolate. This enzyme links the methylation pathway through synthesis of the methyl donor S-adenosyl methionine and the pathway in which purine and pyrim...

Vitamin B-12 deficiency is a common problem encountered in developing countries of the world. In Europe and North America it is frequently encountered in the elderly and in people whose diets are compromised such as alcoholics. Recent data has shown that cobalamin deficiency may occur in 5% to 40% of the general population. The prevalence as stated earlier is higher in the elderly and in nursin...