نتایج جستجو برای: virotherapy

تعداد نتایج: 1060  

2017
Faris Farassati

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Journal: :Cancer research 2005
Thomas Wirth Florian Kühnel Bettina Fleischmann-Mundt Norman Woller Meta Djojosubroto Karl Lenhard Rudolph Michael Manns Lars Zender Stefan Kubicka

Hepatocellular carcinomas (HCC) are drug-resistant tumors that frequently possess high telomerase activity. It was therefore the aim of our study to investigate the potential of telomerase-dependent virotherapy in multimodal treatment of HCC. In contrast to normal liver, HCC xenografts showed high telomerase activity, resulting in tumor-restricted expression of E1A by a telomerase-dependent rep...

2016
Michelle J. Wilkinson Henry G. Smith Timothy D. Pencavel David C. Mansfield Joan Kyula‐Currie Aadil A. Khan Gráinne McEntee Victoria Roulstone Andrew J. Hayes Kevin J. Harrington

The management of locally advanced or recurrent extremity sarcoma often necessitates multimodal therapy to preserve a limb, of which isolated limb perfusion (ILP) is a key component. However, with standard chemotherapeutic agents used in ILP, the duration of response is limited. Novel agents or treatment combinations are urgently needed to improve outcomes. Previous work in an animal model has ...

2015
Carolien A.E. Koks Steven De Vleeschouwer Norbert Graf Stefaan W. Van Gool

Oncolytic viruses have been seriously considered for glioma therapy over the last 20 years. The oncolytic activity of several oncolytic strains has been demonstrated against human glioma cell lines and in in vivo xenotransplant models. So far, four of these stains have additionally completed the first phase I/II trials in relapsed glioma patients. Though safety and feasibility have been demonst...

Journal: :Annals of hepatology 2008
Daniel Y Sze Tony R Reid Steven C Rose

Oncolytic virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral particles to infect neighboring cells and di...

2015
Janice Kim Robert R. Hall Maciej S. Lesniak Atique U. Ahmed E. Antonio Chiocca Martine L.M. Lamfers

Oncolytic virotherapy for cancer is an innovative therapeutic option where the ability of a virus to promote cell lysis is harnessed and reprogrammed to selectively destroy cancer cells. Such treatment modalities exhibited antitumor activity in preclinical and clinical settings and appear to be well tolerated when tested in clinical trials. However, the clinical success of oncolytic virotherapy...

2012
Jianjun Paul Tian Yang Kuang Hanchun Yang

The intracellular viral life-cycle is an important process in tumor virotherapy. Most mathematical models for tumor virotherapy do not incorporate the intracellular viral life-cycle. In this article, a model for tumor virotherapy with the intracellular viral life-cycle is presented and studied. The period of the intracellular viral life-cycle is modeled as a delay parameter. The model is a nonl...

2015
Nicolas AS Sokolowski Helen Rizos Russell J Diefenbach

Oncolytic virotherapy exploits the properties of human viruses to naturally cytolysis of cancer cells. The human pathogen herpes simplex virus (HSV) has proven particularly amenable for use in oncolytic virotherapy. The relative safety of HSV coupled with extensive knowledge on how HSV interacts with the host has provided a platform for manipulating HSV to enhance the targeting and killing of h...

2015
Boris Simovic Scott R Walsh Yonghong Wan

Immunotherapy and oncolytic virotherapy have both shown anticancer efficacy in the clinic as monotherapies but the greatest promise lies in therapies that combine these approaches. Vesicular stomatitis virus is a prominent oncolytic virus with several features that promise synergy between oncolytic virotherapy and immunotherapy. This review will address the cytotoxicity of vesicular stomatitis ...

2013
Gholamreza Motalleb

New cancer therapies with novel mechanisms and functions are needed to treatpatients with different cancers. Virotherapy is a good scenario for such treatment. The advantages of virotherapy include the potential lack of cross resistance with standard therapies and the ability to cause tumor destruction by numerous mechanisms. Oncolytic virus not only possesses unique mechanisms of action that a...

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