BACKGROUND It is suggested that disturbed CSF dynamics are involved in the pathophysiology of idiopathic normal pressure hydrocephalus (INPH). The pulsatility curve describes the relationship between intracranial pressure (ICP) and the amplitude of cardiac related ICP pulsations. The position of baseline ICP on the curve provides information about the physiological state of the CSF dynamic syst...

INTRODUCTION Even though renal function decline is considered relentless in chronic kidney disease (CKD), improvement has been shown in patients with hypertensive nephropathy. Whether this can occur in any type of nephropathy and at any stage is unknown as are the features of patients who improve. METHODS We identified 406 patients in the NephroTest cohort with glomerular filtration rates (mG...

Goal. To analyze the qualitative characteristics of local raw materials different origins and assess prospects its rational use as a source organic matter for production various types improvers secondary in Ukraine soil improvers, Methods. Laboratory — study agrochemical properties main materials, conducted according to certified methods, followed by statistical data processing. Results. The ar...

This study assessed the sustained effect of a physical activity (PA) counseling intervention on PA one year after intervention, predictors of sustained PA participation, and three classes of post-intervention PA trajectories (improvers, maintainers, and decliners) in 238 older Veterans. Declines in minutes of PA from 12 to 24 months were observed for both the treatment and control arms of the s...

The years immediately following the widespread interest in patient safety and then healthcare quality saw considerable debate between pragmatically oriented improvers and research-oriented evaluators —or between ‘evangelists’ and ‘snails’ as one longtime observer characterised the two groups. Too often, enthusiastic improvers (‘evangelists’) relied on simple pre-post designs within a single con...

This paper presents the results of the ASAI (Automotive SPICE Assessors and Improvers) working group. The aim of the ASAI is to address open issues in the real application of the standard Automotive SPICE in the automotive industry. The outcomes of the ASAI activities are a set of guidelines on how some relevant open issues (expressed by means of questions) can be addressed and solved. These gu...

INTRODUCTION Tyrosine kinase inhibitors (TKI) are medications of interest in the treatment of Systemic Sclerosis (SSc) because of their ability to inhibit pathways involved in fibrosis. In this open-label pilot trial, our objectives were to assess the safety, efficacy, and molecular change associated with treatment of patients with diffuse cutaneous (dc)SSc with the TKI nilotinib (Tasigna™). ...

Children's behavior problems may stem from ineffective cortical mechanisms for regulating negative emotions, and the success of interventions may depend on their impact on such mechanisms. We examined neurophysiological markers associated with emotion regulation in children comorbid for externalizing and internalizing problems before and after treatment. We hypothesized that treatment success w...