BACKGROUND The present study investigated whether prochlorperazine affects vestibulo-ocular reflex (VOR) and vestibulo-perceptual function. METHODS We studied 12 healthy naïve subjects 3 h after a single dose of oral prochlorperazine 5 mg in a randomised, placebo-controlled, double-blind, crossover study in healthy young subjects. Two rotational tests in yaw were used: (1) a threshold task in...

A quantitative electro-oculographic method was used to assess the impairment in smooth-pursuit and vestibulo-ocular reflex suppression eye movements in 12 epileptic patients and eight normal volunteers. Both types of eye movement were impaired by a factor of 40% in the epileptic patients, and the impairment was at least partly due to the treatment with phenytoin and phenobarbitone. There was a ...

Abstract Background Vertigo and dizziness are very common complaints that may be related to epilepsy. The purpose of this study was assess vestibulo-spinal linear vestibulo-ocular function in epileptic patients the inter ictal period. current observational carried out audio-vestibular unit Menoufia University. Subjects were divided into two groups: control group included 30 normal individuals n...

Loss of vestibulo-ocular reflexes occurred in two patients with acute supratentorial lesions who received therapeutic doses of anticonvulsant drugs. There was no clinical or angiographic evidence of focal brain-stem damage. Absence of vestibulo-ocular reflexes is attributed to a combination of acute cerebral damage and anticonvulsant drugs. The loss of these reflexes in patients with acute cere...

We have shown previously that the gain of the horizontal vestibulo-ocular reflex (HVOR) is modified by afferent signals from extraocular muscle proprioceptors in the decerebrate pigeon. We have now analysed the variability of the HVOR in intact, alert pigeons and, using the artificial vestibulo-ocular reflex method, have found that in all of the pigeons tested afferent signals from the extraocu...

The vestibular system provides an attractive model for understanding how changes in cellular and synaptic activity influence learning and memory in a quantifiable behavior, the vestibulo-ocular reflex. The vestibulo-ocular reflex produces eye movements that compensate for head motion; simple yet powerful forms of motor learning calibrate the circuit throughout life. Learning in the vestibulo-oc...