Nanoscopic and uniform unilamellar vesicles, rich in cholesterol, have been prepared by a new procedure, named “DELOS-SUSP”, which is based on the depressurization of a cholesterol solution in CO2-expanded acetone into an aqueous solution containing a surfactant. The CO2 is used here as a cosolvent medium, allowing the straightforward preparation of vesicular systems with controlled size distri...

The regulatory mechanisms that control intracellular vesicular trafficking play important roles in cellular function and viability. Neurons have specific vesicular trafficking systems for synaptic vesicle formation, release and recycling. Synaptic vesicular trafficking impairments induce neuronal dysfunction and physiological and behavioral disorders. Parkinson’s disease (PD) is an age-dependen...

Vesicular system drug design has revitalised the efficacy of previous medications by effectively regulating and sustaining their therapeutic action. The objective this study is to evaluate feasibility utilizing pharmaceutical interventions target novel vesicular delivery systems. innovative medication administration minimize adverse effects while ensuring at a predetermined or reasonably consis...

Objective(s): Omega-3 fatty acids play a key role in maintaining human health. The present study aimed to reduce the fishy smell and taste of omega-3 fatty acids through the encapsulation of lipid vesicles. Materials and Methods: Different non-ionic surfactants from the sorbitan ester family and egg lecithin with cholesterol were utilized to form micro-niosomal and liposomal formulations ...

Tonic GABA type A (GABAA) conductance is a key factor regulating neuronal excitability and computation in neuronal networks. The magnitude of the tonic GABAA conductance depends on the concentration of ambient GABA originating from vesicular and non-vesicular sources and is tightly regulated by GABA uptake. Here we show that the transport system regulating ambient GABA responsible for tonic GAB...

Transdermal drug delivery is a dosage form that applied topically to the skin layer (epidermis) which helps deliver into before entering systemic circulation. Ethosomes are soft, and flexible vesicles in rapid absorption. have better pharmaceutical properties than conventional liposomes such as room temperature stability, improved compatibility with Stratum Corneum barrier. non-toxic nature can...

hydatid disease is a common and major public health issue caused by parasite echinococcus granulosus . the highest prevalence of the parasite can be found in different parts of world like africa, australia, and south america. this infection can occurs in almost any part of the body. here we present clinical, radiological, histological features and treatment of a multi ve­sicular osseous hydatid...