نتایج جستجو برای: vesicle brain
تعداد نتایج: 512131 فیلتر نتایج به سال:
Synapse-specific vesicle pools have been widely characterized at central terminals. Here, we demonstrate a vesicle pool that is not confined to a synapse but spans multiple terminals. Using fluorescence imaging, correlative electron microscopy, and modeling of vesicle dynamics, we show that some recycling pool vesicles at synapses form part of a larger vesicle "superpool." The vesicles within t...
objective: mitochondria is a critical organelle within the cell and has important role in the oocyte development, thus the aim of this study was the comparison of mitochondrial distribution within the mouse oocyte at germinal vesicle (gv), germinal vesicle breakdown (gvbd) and metaphase ii (mii) stages using laser confocal microscopy (lscm). materials and methods: after superovulation of adult...
BACKGROUND Blood-brain barrier (BBB) disruption aggravates brain injury induced by intracerebral hemorrhage (ICH); however, the mechanisms of BBB damage caused by ICH remain elusive. Mfsd2a (major facilitator superfamily domain containing 2a) has been known to play an essential role in BBB formation and function. In this study, we investigated the role and underlying mechanisms of Mfsd2a in BBB...
Synaptic vesicle biogenesis involves the recycling of synaptic vesicle components by clathrin-mediated endocytosis from the presynaptic membrane. stoned B, a protein encoded by the stoned locus in Drosophila melanogaster has been shown to regulate vesicle recycling by interacting with synaptotagmin. We report here the identification and characterization of a human homolog of stoned B (hStnB). H...
A novel post-translational modification of threonine, β-N-acetylglucosaminyl-phosphate, was recently discovered on assembly protein AP180, a protein which plays a crucial role in clathrin coated vesicle formation in synaptic vesicle endocytosis (SVE). Herein, we report studies aimed at probing the effect of this modification on binding to proteins in rat brain lysate using pull down experiments...
Background Exocytosis in photoreceptors involves fusion of vesicles with the plasma membrane at base a specialized proteinaceous electron-dense structure known as synaptic ribbon. The molecular mechanisms underlying exocytosis ribbon synapses are not well understood. Research suggests compound model where undergo homotypic forming larger prior to membrane. But how this process is mediated remai...
Biomimetic vesicle prototissues have been designed as a model for cellular tissues. Prototissues display spheroidal or sheet like morphologies, and predictable vesicle–vesicle adhesion strengths, typical sizes, degree of compaction.
Drug delivery across the blood–brain barrier (BBB) has several challenges, especially toward targeting neurological diseases, due to tight and selective function of BBB. Several structural functional components this contribute restricting drug entry, such as interendothelial junctions (TJs), efflux transporters, drug-metabolizing enzymes, crosstalk between cells neurovascular unit. Among differ...
We propose here the application of synaptic vesicle proteins isolated from rat brain as a sole substrate for the specific endoproteinase activities of all seven serotypes of Botulinum Neurotoxin (BoNT/A to G). In this study, we used these proteins for evaluating endopeptidase and receptor binding activity for detecting BoNT/A by western blot and surface plasmon resonance with 6.25 pM and 0.22 f...
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