The vervet monkey (Chlorocebus aethiops, formerly Cercopithecus aethiops) has long been among the most important non-human primate (NHP) models for biomedical research, with a PubMed citation record (over the past 10 years) close to that of rhesus macaque and much greater than that of any other NHP. The dramatic recent growth in the use of vervet as a model derives in part from its recognized u...

The use of non-human primates provides an excellent translational model for our understanding of developmental and aging processes in humans(1-6). In addition, the use of non-human primates has recently afforded the opportunity to naturally model complex psychiatric disorders such as alcohol abuse(7). Here we describe a technique for blocking the brain in the coronal plane of the vervet monkey ...

A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fluid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

Eleven vervet monkeys (Cercopithecus aethiops) were fed with an "O" protein diet. After the serum albumin level fell below 2.5 g/100 ml the animals and 4 controls, which received regular monkey chow, were orally infected with a monkey-adapted strain of Vibrio cholerae. The total bactericidal activity of the jejunal fluid decreased during feeding with "O" protein diet, but increased after challe...

T HE BABOON (Papio anuliis and Papio thioceplialus) is becoming an increasingly important animal for laboratory investigation. On account of its greater size and the ease with which large quantities of blood can be withdrawn and multiple marrow and other biopsies taken, it is replacing the rhesus monkey (Macaca niulatta). Its temperament is equable and the animals are more reliable than the sma...

Electron microscopy revealed that 80% of captured vervet monkeys, held in quarantine for experimental use, showed extensive proliferation of spiral-shaped bacteria on the mucosal epithelium of the large bowel. A consortium, consisting of a predominant spirillum together with a spirochaete, was usually seen as a lawn covering the colonic epithelium. Sparsely populated areas showed preferential c...