BACKGROUND Left ventricular enlargement with normal systolic function is common in asymptomatic relatives of patients with familial dilated cardiomyopathy, many of whom progress to overt dilated cardiomyopathy at follow up. OBJECTIVE To examine maximal and submaximal gas exchange variables of cardiopulmonary exercise testing in asymptomatic relatives with left ventricular enlargement. DESIG...

In order to understand more precisely the progression of ventricular dysfunction in hypertension prior to development of ventricular failure, 25 normal volunteer subjects and 97 untreated essential hypertensive patients (21 of whom had coronary arteriography and failed to show significant atherosclerosis) were classified into three groups: (I) normal-sized hearts, 54 patients; (II) left atrial ...

Serial computed tomographic scans in 39 closed head injury patients were measured by planimetry. The ventricle-brain ratio was computed, and the lateral ventricles were considered to be enlarged or normal based on measurements from a control group. Delayed ventricular enlargement was common after head injury producing low Glasgow Coma Scale scores and prolonged coma, whereas subarachnoid/intrav...

OBJECTIVE To determine the relation of neonatal cranial ultrasound abnormalities to autism spectrum disorders (ASD) in low birth weight (LBW) adult survivors, a population at increased ASD risk. STUDY DESIGN This is a secondary analysis of a prospectively-followed regional birth cohort of 1105 LBW infants systematically screened for perinatal brain injury with cranial ultrasound in the first ...

Picture 1. (A) A chest X-ray showing enlargement of the right atrium (RA) (arrow), (B) An echocardiogram showing dilatation of the coronary sinus (CS) (arrow), (C) A multislice computed tomogram showing enlargement of the RA, (D) A multislice computed tomogram showing persistent left superior vena cava (SVC) (arrow) which drained into the RA through the CS. LAD: left atrial dimension, LVDd: lef...

An acute myocardial infarction, particularly one that is large and transmural, can produce alterations in the topography of both the infarcted and noninfarcted regions of the ventricle. This remodeling can importantly affect the function of the ventricle and the prognosis for survival. In the early period, infarct expansion has been recognized by echocardiography as a lengthening of the noncont...

Parkinson's disease (PD) typically manifests with asymmetric motor symptom onset. Ventricular enlargement, a nonspecific measure of brain atrophy, has been associated with cognitive decline in PD, but not with motor symptom asymmetry. Asymmetrical ventricular enlargement on magnetic resonance images was explored in a monozygotic twin pair discordant for PD and in nine healthy monozygotic twin p...

BACKGROUND Coronary artery enlargement has been previously described in left ventricular hypertrophy. OBJECTIVES We sought to assess coronary artery dimensions and their relation to left ventricular muscle mass in primary and secondary hypertrophy. METHODS Cross-sectional area of the left and right coronary arteries was determined by quantitative coronary angiography in 52 patients: 12 cont...