background: henoch-schönlein purpura (hsp) is an lga mediated small vessel systemic vasculitis disease in children. the etiology and pathogenesis of hsp disease remain unknown. however, environmental and genetic risk factors could play important roles in susceptibility to hsp disease. in this study we investigated the association of 5՛-untranslated region polymorphism (-634g/c) of vegf gene wit...

Background: Vascular endothelial growth factor (VEGF) is an angiogenic growth factor that is produced by different tissues, including the endometrium and ovary. VEGF is involved in many processes related to reproductive physiology, including angiogenesis, which is essential for implantation and placentation. It has been suggested that VEGF may be the angiogenic factor responsible for the implan...

vascular endothelial growth factor (vegf-a) is one of the most important regulatory factors in pathological and physiological angiogenesis. alternative splicing is a complicated molecular process in vegf-a gene expression which adds complexity to vegf-a biology. among all vegf-a exons, alternative splicing of exon 8 is the key determinant of isoform switching from pro-angiogenic vegf-xxx to ant...

Background Spontaneous abortion has been defined as two or more consecutive miscarriages at 20 weeks pregnancy. Vascular endothelial growth factor (VEGF) plays a main role in fetal and placental angiogenesis which secretes from different cells like endometrium and placenta.The objective of this study was to investigate of association of VEGFA gene polymorphisms and recurrent spontaneous abortio...

Background: Several studies have shown that leukemia inhibitory factor (LIF) is one of the most important cytokinesparticipating in the process of embryo implantation and pregnancy, while, the role of this factor on vascular endothelialfactor-A (VEGF-A), as one of the most important angiogenic factor, has not been fully investigated yet. The aimof this study was to evaluate th...

background vegf gene has been reported to be related with many diseases and recurrent pregnancy loss in various studies. vegf polymorphisms are risk factors for pregnancy losses, and generally studies report only women’s genetic analyses. to evaluate the association between vegf a c405g, c460t, c936t and c2578a polymorphisms and spontaneous abortion, we studied the genotypes of spontaneously ab...

Objective(s): Progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. It is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. Material and Methods: Adult female NMRI mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimu...