BACKGROUND Tamoxifen (TAM) is a nonsteroidal antiestrogen that has been widely used in the treatment of breast cancer through its anti-estrogen activity. Recent studies show that TAM is cytotoxic to both estrogen receptor (ER)-positive and ER-negative cells via the induction of apoptosis. However, the molecular mechanisms of this effect are not well understood. In the present study, we investig...

Purpose – Given the widespread popularity of social media, such as Twitter, Facebook, Googleþ , and LinkedIn, theorizing and understanding the user attitude and usage behavior of social media site is fundamental in developing future understandings and deployment of these new technologies. One approach to such studies on drivers of social media usage behavior would be to revisit the technology a...

For a task of natural language understanding, the identification of tense, aspect and mood (TAM) features in a given text is of importance in itself. A closer look at the verb groups in a sentence can give the exact combination of the TAM features the verb group carries. While the verb group consisting of one word could be easily interpreted for the TAM features, the TAM features of the verb gr...

Generally speaking, technology acceptance model (TAM, Davis, et al., 1989; Davis, 1989) is a successful model and prior studies have explored the TAM from different perspectives and many antecedents have been identified. However, the overview of TAM shows that the explanatory power of TAM is limited. Furthermore, more and more inconsistencies in results appeared along with the development of TA...

A statistical meta-analysis of the technology acceptance model (TAM) as applied in various fields was conducted using 88 published studies that provided sufficient data to be credible. The results show TAM to be a valid and robust model that has been widely used, but which potentially has wider applicability. A moderator analysis involving user types and usage types was performed to investigate...

Purpose – The purpose of this paper is to review the literature on information technology adoption in organizations to understand the need of integrated models for technology adoption. It further makes an attempt to identify key parameters to integrate technology acceptance model (TAM) and technology-organization-environment (TOE) framework for firm level technology adoption. This integration i...

Involvement of the immune system in tumour progression is at the forefront of cancer research. Analysis of the tumour immune microenvironment has yielded a wealth of information on tumour biology, and alterations in some immune subtypes, such as tumour-associated macrophages (TAM), can be strong prognostic indicators. Here, we use optical tissue clearing and a TAM-targeting injectable fluoresce...

Experiments were designed to investigate whether the tumor-associ ated macrophage (TAM) content of murine solid tumors correlates with the clonogenic ability of tumor cells to establish s.c. tumors, tumor growth rate, extent of tumor necrosis, tumor metastatic propensity, and tumor radioresponse. Of 13 tumors studied, 6 were sarcomas and 7 were carcinomas; all tumors were of spontaneous origin ...

This paper presents research exploring further the concept that many SMEs do not adopt computer based technologies due to decision maker’s negative attitudes towards computers generally. Importantly, by assessing the entrepreneur’s belief structure, we provide quantitative evidence how SMEs, particularly micros, are affected. Earlier research that addresses technology acceptance model (TAM) sug...