The validation of surface-recovery methods is a pre-requisite for residual determination of cleaning effectiveness in process validation studies. These methods should be challenged in the laboratory using pilot-scale controlled conditions in order to evaluate the suitability for their intended use. Different swabbing techniques have been studied and compared with rinse method for 7 microorganis...

In the present study, the potential of a bacterial consortium of Enterobacter cloacae and Pseudomonas sp. (ERCPPI-2) for microbial enhanced oil recovery was investigated. Various mechanisms of enhanced oil recovery (EOR) as a result of using ERCPPI-2 and its metabolic products were studied in detail. The obtained results showed that under simulated reservoir ...

1. Better bacterial inactivation was observed with higher ultraviolet (UV) doses. There is a need for better tank configuration (hydraulic performance) to ensure proper water circulation or a need to suppress microbial recovery. Addition of titanium dioxide (TiO2) during UV irradiation was effective in controlling microbial recovery. 2. Higher water temperature enhanced the fouling rate on quar...

Neutralization method evaluation is an important first step in a disinfectant validation study program. It is also crucial in assessment of the efficiency of microbial recovery media in the presence of a residual biocidal agent. In the present study, four commercially available peroxygen/silver-based disinfectant formulae--intended to be used in a pharmaceutical facility sanitization program--w...

Microbial fuel cell and microbial electrolysis cell are two major types of microbial electrochemical cells. In the present study, we governed modeling of these systems by concentrating on the simulation of bioelectrochemical reactions in both biofilm and anolyte and considering the effect of pH on the microbial growth. The simulation of microbial fuel and electrolysis cells can be described by ...

Sufficient number of linear and noisy measurements for exact and approximate sparsity pattern/support set recovery in the high dimensional setting is derived. Although this problem as been addressed in the recent literature, there is still considerable gaps between those results and the exact limits of the perfect support set recovery. To reduce this gap, in this paper, the sufficient con...

Validation of methods for microbial detection in foods or other matrices involves determining microbe recoveries. Recoveries are expressed qualitatively as presence-absence data, which are obtained from quantitative spiking experiments. Replicate samples of foods are spiked with the microbe of interest, generally at several concentration levels. Usually three different levels are used. However,...

In recent years, cleaning validation has achieved a position of increasing in the pharmaceutical industry. It provides assurance to the cleaning procedure that ensures equipment is consistently cleaned from the product, detergent and microbial residues to an acceptable level to avoid cross-contamination and adulteration of drug product with other active ingredients. The aim of this study was to...