The oral antiviral valacyclovir, which is 3 to 5 times more bioavailable than its parent compound acyclovir, is a good candidate for effective therapy to suppress recurrent herpes labialis lesions. The efficacy of oral valacyclovir in the suppression of herpes labialis has not previously been reported. Two identical, randomized, double-blind, parallel-group studies were conducted to evaluate th...

OBJECTIVE To compare the efficacy and safety of valacyclovir hydrochloride and famciclovir for the treatment of herpes zoster. DESIGN A double-blind, randomized, controlled, multicenter clinical trial in which patients received 7 days of treatment and were followed up for 24 weeks. SETTINGS Patients reported directly to specialist centers or were referred from primary care centers. PATIEN...

A simple spectrophotometric method has been developed for the estimation of valacyclovir in pharmaceutical preparations. The method is based on the reaction of the valacyclovir with methanolic solution of para dimethyl amino benzaldehyde (PDAB) in acidic condition producing Schiff base having absorption maximum at 400 nm. Beer’s law is obeyed in the concentration of 50-250 μg/mL of valacyclovir...

Equine coital exanthema (ECE) has been reported in many countries, but equine herpesvirus 3 (EHV-3) has been isolated only once in Japan. In 2015, symptoms of ECE were found, and EHV-3 was isolated in two stallions. Valacyclovir, an anti-herpesvirus agent, was administered orally. The stallions rested from mating for more than two weeks, causing enormous financial losses because of their high f...

PURPOSE To test the effect of valacyclovir alone and with aspirin on the asymptomatic shedding of HSV-1 DNA in tears and saliva of healthy individuals. METHOD. The subjects (n = 45) were randomized into three groups without regard to age, sex, or race. Group 1 (n = 14) received the placebo, group 2 (n = 15) received a dose of 500 mg valacyclovir once daily, and group 3 (n = 16) received a dose ...

UV-visible and Fluorescence spectroscopic methods were employed to study the interaction of human serum albumin (HSA) with Valacyclovir Hydrochloride. Additionally, molecular dynamics and molecular docking simulations were used to visualize and specify the binding site of Valacyclovir Hydrochloride. The Stern-Volmer and van't Hoff equations along with spectroscopic observations, were used to de...

Many species of tsetse flies are infected with a virus that causes salivary gland hypertrophy (SGH) symptoms associated with a reduced fecundity and fertility. A high prevalence of SGH has been correlated with the collapse of two laboratory colonies of Glossina pallidipes and colony maintenance problems in a mass rearing facility in Ethiopia. Mass-production of G. pallidipes is crucial for prog...

(including tissue-invasive CMV disease) in 616 ganciclovir; prophylaxis; renal transplantation; recipients of cadaveric renal allografts [2]. Two hun-valacyclovir dred and eight patients were assigned to the CMV high-risk group (CMV positive donor and a CMV negative receptor); this group was called the sero-negative group. Valacyclovir in a dose of 2 g q.i.d. Introduction (adjusted for renal fu...

Valacyclovir is the 5'-valyl ester prodrug of acyclovir, an effective anti-herpetic drug. Systemic availability of acyclovir in humans is three to five times higher when administered orally as the prodrug. The increased bioavailability of valacyclovir is attributed to carrier-mediated intestinal absorption, via the hPEPT1 peptide transporter, followed by the rapid and complete conversion to acy...

background and objective: cytomegalovirus (cmv) infections are associated with severe morbidity and mortality in patients, especially pediatric renal transplantation patients. the use of immunosuppressive agents places these patients at the risk of viral infections. as cytomegalovirus infection influences the graft outcome, adopting useful strategies for limiting this virus after transplantatio...