Welders are more susceptible to pneumococcal pneumonia. The mechanisms are yet unclear. Pneumococci co-opt the platelet activating factor receptor (PAFR) to infect respiratory epithelial cells. We previously reported that exposure of respiratory cells to welding fumes (WF), upregulates PAFR-dependent pneumococcal infection. The signaling pathway for this response is unknown, however, in intesti...

BACKGROUND A compact pre-filled auto-disable injection (cPAD) presentation is being developed for the fully liquid pentavalent DTP-HepB-Hib vaccine. A cost analysis (CA) to compare this presentation with the presently used single-dose vial (SDV) and multi-dose vial (MDV) was conducted in Cambodia, Ghana, and Peru. METHODOLOGY The CA included the development of an excel-based costing model and...

Introduction: By July 2023, Brazil had administered approximately 540 million COVID-19 vaccine doses. This study aimed to quantify wasted doses resulting from dead space in supplies. Methods: The supply was initially weighed, filled with distilled water, and expelled simulate administration. Weighing it again after the application determined volume. Descriptive analyses calculated waste rate/wa...

BACKGROUND Reducing vaccine wastage is important. Bacille Calmette-Guérin (BCG) vaccine is produced in vials of 20 infant doses. The reconstituted vaccine is discarded after 4-6 hours. Therefore, to reduce vaccine wastage, a 20-dose vial of BCG is often only opened if at least 10-12 infants are present, jeopardising BCG vaccination coverage and timely vaccination. We observed that nurses were n...

background: in radiotherapy, wedge filters are used for optimizing the tumor dose distribution in patients. the attenuation in beam intensity due to the presence of wedge filter is compensated by means of a wedge factor measured at the central axis of the beam. the field size, depth and ssd dependence of wedge factor have been assessed for 9mv radiations of neptun pc linear accelerator. materia...

OBJECTIVE To provide global policy-makers with decision-making information for developing strategies for immunization of infants with a birth dose of hepatitis B vaccine, this paper presents a retrospective cost analysis, conducted in Indonesia, of delivering this vaccine at birth using the Uniject prefill injection device. METHODS Incremental costs or cost savings associated with changes in ...

Background: In radiotherapy, wedge filters are used for optimizing the tumor dose distribution in patients. The attenuation in beam intensity due to the presence of wedge filter is compensated by means of a wedge factor measured at the central axis of the beam. The field size, depth and SSD dependence of wedge factor have been assessed for 9MV radiations of Neptun PC linear accelerator. Materia...