The window of implantation is defined by the inhibition of uterine epithelial proliferation, structural epithelial cell remodeling, and attenuated estrogen (E2) response. These changes occur via paracrine signaling between the uterine epithelium and stroma. Because implantation defects are a major cause of infertility in women, identifying these signaling pathways will improve infertility inter...

Background: Our current knowledge of the epidemiology and the most common cause of infertility are limited and outdated in our geographic area. It is known that, one important cause of infertility is female factor. This study was done to investigate the incidence of female factor and the most common cause of female infertility in patients of Kermanshah infertility treatment center in Mo'ta...

Background Infertility is defined as failure in pregnancy after one year of unprotected intercourse. Several centers have reported different causes of infertility. The most common causes of infertility are: male factor such as sperm disturbance, female factor such as ovulation dysfunction and tubal factor, both male and female factor, and unexplained infertility .The aim of this study was to su...

Background More than 3 decades after the introduction of in vitro fertilization (IVF) and despite the improved success rates of assisted reproductive technologies, the argument for performing laparoscopy as a part of the infertility workup still stands. Objective To evaluate the role of laparoscopy±hysteroscopy in diagnosis and management of infertility in our setting in view of modern fertil...

Embryo implantation requires healthy uterine endometrium for natural or assisted reproductive technology conception. However, in presence of any endometrial anatomical abnormality disease, is affected. Uterine polyps are over growths cells that extend into the cavity. They usually noncancerous. There can be one many polyps. range size from a few millimeters to several centimeters larger. may ca...

background: mullerian disorders are present in 5-25% of infertile women. myoma, polyp and endometrial adhesions are among other involved factors in infertility. objective: the aim of this study was to determine the frequency distribution of pregnancy occurrence in infertile women after the diagnostic-surgical hysteroscopy on selected infertile cases including those with abnormal uterine. materi...

Fertility outcome following laparoscopic myomectomy was evaluated. A prospective clinical study was carried out between October 1990 and October 1993 in 21 infertile patients who underwent laparoscopic myomectomy for a myoma measuring > or = 5 cm in diameter. The overall rate of intrauterine pregnancy was 33.3% (seven patients). Out of 12 patients with infertility factors associated with uterin...

Uterine transplantation is an evolving procedure to allow for childbearing in paitents with absolute uterine factor infertility. The objective of this study was review the existing literature using a comprehensive PubMed search. A systematic medical subheadings search strategy used terms “uterus transplant” and “uterine transplantation”. Of 75 full-text articles assessed eligibility, 68 were in...

BACKGROUND Embryo implantation requires a healthy embryo and a receptive uterus. Uterine incompetence contributes significantly to implantation failure and infertility. To date, there are no reliable biochemical methods that can determine whether the uterus is receptive. Proprotein convertase 5/6 (PC6) is tightly regulated in the uterus and critical for receptivity and implantation; its secreto...