background: punica granatum linn. (pg) is native to the mediterranean region. its flower exhibited antioxidant activity. the present study attempt to investigate the effect of these extract on uterine contraction and its possible mechanism(s). methods: thirty five female wistar rats (200-300 g) at estrous phases of cycle was examined in this study; pieces of virgin adult rat uterus (1.5 cm) wer...

Objective The aim of this study was to investigate the effect and mechanism by which progesterone regulates uterine contraction in late pregnant rats. Results Progesterone caused concentration-dependent relaxation of uterine strips that was enhanced compared with control nontreated uterine strips. Uterine strips incubated with progesterone showed a significant increase in TREK-1 mRNA expressi...

The mechanism of uterine muscle contraction stimulated by a triterpenoid glycoside (dalsaxin) isolated from the root of D. saxatilis was investigated by in vitro methods in the rat. Dalsaxin caused a dose-related increase in uterine muscle contraction. The contraction was single and transient and was abolished by moderate doses of isoprenaline (1.80 nmol-0.40 mumol) and salbutamol (0.13-25 mumo...

Normal pregnancy is associated with uterine relaxation to accommodate the stretch imposed by the growing fetus; however, the mechanisms underlying the relationship between pregnancy-associated uterine stretch and uterine relaxation are unclear. We hypothesized that increased uterine stretch during pregnancy is associated with upregulation of matrix metalloproteinases (MMPs), which in turn cause...

BACKGROUND During labor, ephedrine is widely used to prevent or to treat maternal arterial hypotension and restore uterine perfusion pressure to avoid intrapartum fetal asphyxia. However, the effects of ephedrine on uterine blood flow have not been studied during uterine contractions. The purpose of the study was to assess the effects of ephedrine on uterine artery velocities and resistance ind...

The aim of this study is to simulate the contraction phenomena in pregnant uterine. Differential equations are used to model the uterine contractions for three states, namely contracting, refractory, and resting. Since verification and validation are vital for simulation systems, we compared our model with uterine magnetomyogram (MMG) data which are recorded non-invasively using SQUID-Array for...

Previous work in our laboratory showed that o,p'-DDT increases the frequency of rat uterine contractions in vitro. The present study investigated whether this response was related to prostaglandin E 2 (PGE2) release from the uterine strips or to the estrogenicity of o,p'-DDT. Contraction frequency was evaluated by recording isometric spontaneous contractions in longitudinal uterine strips from ...

BACKGROUND The present study demonstrates the expression of intermedin (IMD) and its receptor components in the uterus of the female rat during the estrous cycle and its effect on uterine contraction. METHODS The gene expression level of intermedin and its receptor components and the peptide level of intermedin were studied by real-time RT-PCR and enzyme immunoassay (EIA) respectively. The se...

In clinical trial study, effect of ampicillin on idiopathic premature labor in 16 hospitals for 4 months from 74/09/30 was evaluated. (Tehran, 1995). Cases (30 subjects) have received ampicillin, but controls (30 subjects) didn't receive it. In two groups, maternal age, gestational age, parity, vaginal examination (lillatation & effacement), uterine contractions within 10 minutes, tocolytic dru...

background: dystocia is the most common indication of primary cesarean section. the most common cause of dystocia is uterine dysfunction. in prolonged labor, more attention is usually paid to the fetus and pelvis rather than to the role of uterine contractions in a delivery. therefore, we decided to determine the relationship between the labor progress and uterine contractions shapes . methods:...