Hog thyroid tautomerase (EC 5.3.2.1, phenylpyruvate keto-enol isomerase), an enzyme which is believed to play a role in the biosynthesis of thyroxine, has been purified over lOOO-fold. The purification procedure involves a heat step at 70”, gel f&ration on Sephadex G-100, ion exchange chromatography on carboxymethyl Sephadex C-50, and, finally, gel titration on Sephadex G-50. The enzyme is homo...

Hepatitis C virus (HCV) will continue to be a serious global health threat for many years to come because of the chronic nature of the infection, its high prevalence and the significant morbidity of the resulting disease. Recently, a small number of molecules have produced encouraging results in proof-of-concept clinical trials. At the same time, preclinical evidence is accumulating that develo...

Francesco Ruggiero (1957–2007) was a brilliant accelerator physicist, an inventive researcher, a great collaborator, an excellent mentor, and a true gentleman. We here take a look at Francesco’s scientific work, and highlight some of his contributions to accelerator physics. More details can be found in the slides presented by the speakers of the Francesco Ruggiero Memorial Symposium held at CE...

Section of Rheumatology, Department of Clinical and Experimental Medicine, University of Ferrara, Italy. Francesco De Leonardis, MD Marcello Govoni, MD Andrea Lo Monaco, MD, PhD Francesco Trotta, MD Please address correspondence to: Francesco De Leonardis, MD, Section of Rheumatology, Department of Clinical and Experimental Medicine, University of Ferrara, S. Anna Hospital, Corso della Giovecca...